(3S,5S)-3,5-Dimethyl-4-((E)-1-methylene-5-phenyl-pent-2-en-4-ynyl)-morpholine

Base Information

Chemical Name:(3S,5S)-3,5-Dimethyl-4-((E)-1-methylene-5-phenyl-pent-2-en-4-ynyl)-morpholine
CAS No.:154596-25-5
Molecular Formula:C₁₈H₂₁NO
Molecular Weight:267.371
Hs Code.:

Synonyms:(3S,5S)-3,5-Dimethyl-4-((E)-1-methylene-5-phenyl-pent-2-en-4-ynyl)-morpholine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,5S)-3,5-Dimethyl-4-((E)-1-methylene-5-phenyl-pent-2-en-4-ynyl)-morpholine

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Technology Process of (3S,5S)-3,5-Dimethyl-4-((E)-1-methylene-5-phenyl-pent-2-en-4-ynyl)-morpholine

There total 3 articles about (3S,5S)-3,5-Dimethyl-4-((E)-1-methylene-5-phenyl-pent-2-en-4-ynyl)-morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 2579-22-8
Phenylpropargyl aldehyde

: (-)-(S,S)-2-(3,5-dimethylmorpholino)-1-propenyltriphenylphosphonium bromide

: (3S,5S)-3,5-Dimethyl-4-((Z)-1-methylene-5-phenyl-pent-2-en-4-ynyl)-morpholine

: 154596-25-5
(3S,5S)-3,5-Dimethyl-4-((E)-1-methylene-5-phenyl-pent-2-en-4-ynyl)-morpholine

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; Yield given; Heating;
DOI:10.1055/s-1994-25407

Reference yield:

: 154634-96-5,942400-51-3
(+)-(S,S)-3,5-dimethylmorpholine

: 154596-25-5
(3S,5S)-3,5-Dimethyl-4-((E)-1-methylene-5-phenyl-pent-2-en-4-ynyl)-morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / CH₂Cl₂ / 1 h / 25 °C

2: 69 percent / t-BuOK / tetrahydrofuran / Heating

With potassium tert-butylate; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-1994-25407

Reference yield:

: 154634-95-4
(3S,5S)-4-tert-butoxycarbonyl-3,5-dimethylmorpholine

: 154596-25-5
(3S,5S)-3,5-Dimethyl-4-((E)-1-methylene-5-phenyl-pent-2-en-4-ynyl)-morpholine

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / 6 M HCl / ethyl acetate

2: 81 percent / CH₂Cl₂ / 1 h / 25 °C

3: 69 percent / t-BuOK / tetrahydrofuran / Heating

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1055/s-1994-25407