Pyrido[2,3-d]pyrimidin-4-amine

Base Information

• Chemical Name: Pyrido[2,3-d]pyrimidin-4-amine
• CAS No.: 37538-65-1
• Molecular Formula: C₇H₆N₄
• Molecular Weight: 146.151
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID10500480
• Wikidata: Q82352102
• Mol file: 37538-65-1.mol

Synonyms:Pyrido[2,3-d]pyrimidin-4-amine;37538-65-1;Pyrido[2,3-d]pyrimidin-4-amine (9CI);SCHEMBL2041433;4-aminopyrido[2,3-d]pyrimidine;AMY1774;DTXSID10500480;pyrido[3,2-e]pyrimidin-4-yl-amine;AKOS006310802;Pyrido[2,3-d]pyrimidin-4-amine(9ci);FT-0708962;EN300-4289213;J-524130;Z1198236222

Chemical Property of Pyrido[2,3-d]pyrimidin-4-amine

Chemical Property:

• Melting Point: 305-310 °C (decomp)(Solv: ethanol (64-17-5))
• Boiling Point: 349.4±27.0 °C(Predicted)
• PKA: 3.97±0.30(Predicted)
• PSA: 64.69000
• Density: 1.385±0.06 g/cm3(Predicted)
• LogP: 1.18820
• Storage Temp.: 2-8°C
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 146.059246208
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

97% ^*data from raw suppliers

pyrido[2,3-d]pyrimidin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(N=CN=C2N=C1)N

Technology Process of Pyrido[2,3-d]pyrimidin-4-amine

There total 17 articles about Pyrido[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

7-(methylthio)pyrido[2,3-d]pyrimidin-4-amine → 4-aminopyrido[2,3-d]pyrimidine (37538-65-1) + C8H8N4O2S

Guidance literature:

7-(methylthio)pyrido[2,3-d]pyrimidin-4-amine; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 0.666667h;

In ethanol; at 80 ℃;

DOI:10.1021/jm501010f

Reference yield:

2-aminopyridin-3-carboxylic acid (5345-47-1) → 4-aminopyrido[2,3-d]pyrimidine (37538-65-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 170 °C

2: POCl₃

3: NH₃

With ammonia; trichlorophosphate;

DOI:10.1021/ja01613a069

Reference yield:

N-(2-pyridyl-3-methyl)acetamide (7463-30-1) → 4-aminopyrido[2,3-d]pyrimidine (37538-65-1)

Guidance literature:

Multi-step reaction with 4 steps

1: aqueous KMnO₄ / Erwaermen des Reaktionsprodukts mit wss. HCl

2: 170 °C

3: POCl₃

4: NH₃

With potassium permanganate; ammonia; trichlorophosphate;

DOI:10.1021/ja01613a069

upstream raw materials:

4-chloro-pyrido[2,3-d]pyrimidine

4-amino-1H-pyrido[2,3-d]pyrimidine-2-thione

2-amino-N’-hydroxynicotinimidamide

orthoformic acid triethyl ester