2-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-methoxy-3-<1-<(7'-phenylmethoxy)-1'-indanyl>-1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-4-naphthalenol

Base Information

• Chemical Name: 2-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-methoxy-3-<1-<(7'-phenylmethoxy)-1'-indanyl>-1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-4-naphthalenol
• CAS No.: 124887-34-9
• Molecular Formula: C₄₁H₅₆O₅Si₂
• Molecular Weight: 685.064
• Mol file: 124887-34-9.mol

Synonyms:2-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-methoxy-3-<1-<(7'-phenylmethoxy)-1'-indanyl>-1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-4-naphthalenol

Chemical Property of 2-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-methoxy-3-<1-<(7'-phenylmethoxy)-1'-indanyl>-1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-4-naphthalenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-methoxy-3-<1-<(7'-phenylmethoxy)-1'-indanyl>-1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-4-naphthalenol

There total 8 articles about 2-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-methoxy-3-<1-<(7'-phenylmethoxy)-1'-indanyl>-1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-4-naphthalenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1,4-bis<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-<7'-(phenylmethoxy)-1'-indanyl>-2-butyne (124887-33-8) → 2-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-methoxy-3-<1-<(7'-phenylmethoxy)-1'-indanyl>-1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-4-naphthalenol (124887-34-9)

Guidance literature:

With acetic anhydride; In n-heptane; at 80 ℃; for 3h;

DOI:10.1021/jo00293a043

Reference yield: 85.0%

1,4-bis<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-<7'-(phenylmethoxy)-1'-indanyl>-2-butyne (124887-33-8) + pentacarbonyl(1-methoxybenzylidene)chromium(0) (27436-93-7) → 2-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-methoxy-3-<1-<(7'-phenylmethoxy)-1'-indanyl>-1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-4-naphthalenol (124887-34-9)

Guidance literature:

With acetic anhydride; In n-heptane; at 80 ℃; for 3h;

DOI:10.1016/S0040-4039(01)93705-0

Reference yield:

7-hydroxy-indan-1-one (6968-35-0) → 2-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-methoxy-3-<1-<(7'-phenylmethoxy)-1'-indanyl>-1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-4-naphthalenol (124887-34-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 94 percent / potassium carbonate, tetrabutylammonium iodide / dimethylformamide / 10 h / Ambient temperature

2: 1) potassium tert-butoxide / 1) dioxane, 0 deg C , then 0.8 h, RT 2) dioxane, 2 h , RT, then reflux 2h

3: 75 percent / p-toluenesulfonic acid / H₂O; dioxane / 16 h / Heating

4: 1) n-butyllithium / 1) THF, -78 deg C 2) THF, 0 deg C, 2 h

5: imidazole / dimethylformamide / 29 h / Ambient temperature

6: 85 percent / acetic anhydride / heptane / 3 h / 80 °C

With 1H-imidazole; n-butyllithium; potassium tert-butylate; acetic anhydride; tetra-(n-butyl)ammonium iodide; potassium carbonate; toluene-4-sulfonic acid; In 1,4-dioxane; n-heptane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo00293a043

upstream raw materials:

1,4-bis<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-<7'-(phenylmethoxy)-1'-indanyl>-2-butyne

pentacarbonyl(1-methoxybenzylidene)chromium⁽⁰⁾

7-hydroxy-indan-1-one

7-(phenylmethoxy)indan-1-one

Downstream raw materials:

3-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-4-methoxy-1-(phenylmethoxy)-2-<1-<7'-(phenylmethoxy)-1'-indanyl>-1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-methyl>naphthalene

2-<1-oxo-1-<7'-(phenylmethoxy)-1'-indanyl>methyl>-4-methoxy-1-(phenylmethoxy)naphthalene-3-carboxaldehyde

3-(1-Hydroxymethyl)-2-<1-hydroxy-1-<7'-(phenylmethoxy)-1'-indanyl>methyl>-4-methoxy-1-(phenylmethoxy)-naphthalene

2,3-dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<4'-methoxy-9'-(phenylmethoxy)-2'H-benzindene>-1',3'-dione