3-[2-(2,5-dimethylphenoxymethyl)benzoyl]-5-ethoxy-2-isoxazoline

Base Information

• Chemical Name: 3-[2-(2,5-dimethylphenoxymethyl)benzoyl]-5-ethoxy-2-isoxazoline
• CAS No.: 206561-73-1
• Molecular Formula: C₂₁H₂₃NO₄
• Molecular Weight: 353.418
• Mol file: 206561-73-1.mol

Synonyms:3-[2-(2,5-dimethylphenoxymethyl)benzoyl]-5-ethoxy-2-isoxazoline

Chemical Property of 3-[2-(2,5-dimethylphenoxymethyl)benzoyl]-5-ethoxy-2-isoxazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[2-(2,5-dimethylphenoxymethyl)benzoyl]-5-ethoxy-2-isoxazoline

There total 3 articles about 3-[2-(2,5-dimethylphenoxymethyl)benzoyl]-5-ethoxy-2-isoxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl vinyl ether (109-92-2,25104-37-4) + (Z)-2-(2,5-dimethylphenoxymethyl)phenylglyoxylohydroxamyl chloride → 3-[2-(2,5-dimethylphenoxymethyl)benzoyl]-5-ethoxy-2-isoxazoline (206561-73-1)

Guidance literature:

With sodium hydrogencarbonate; In isopropyl alcohol; at 20 ℃;

DOI:10.3987/COM-02-9618

Reference yield:

2'-(2,5-dimethylphenoxymethyl)acetophenone (206561-83-3) → 3-[2-(2,5-dimethylphenoxymethyl)benzoyl]-5-ethoxy-2-isoxazoline (206561-73-1)

Guidance literature:

Multi-step reaction with 2 steps

1: butyl nitrite; HCl / dioxane; diethyl ether / 20 °C

2: NaHCO₃ / propan-2-ol / 20 °C

With hydrogenchloride; n-Butyl nitrite; sodium hydrogencarbonate; In 1,4-dioxane; diethyl ether; isopropyl alcohol;

DOI:10.3987/COM-02-9618

Reference yield:

N-methoxy-N-methyl-2-(2,5-dimethylphenoxymethyl)benzamide → 3-[2-(2,5-dimethylphenoxymethyl)benzoyl]-5-ethoxy-2-isoxazoline (206561-73-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / tetrahydrofuran / 2 h / -45 - 20 °C

2: butyl nitrite; HCl / dioxane; diethyl ether / 20 °C

3: NaHCO₃ / propan-2-ol / 20 °C

With hydrogenchloride; n-Butyl nitrite; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; isopropyl alcohol;

DOI:10.3987/COM-02-9618

upstream raw materials:

ethyl vinyl ether

2'-(2,5-dimethylphenoxymethyl)acetophenone

Downstream raw materials:

3-[2-(2,5-dimethylphenoxymethyl)benzoyl]isoxazole