C₂₂H₂₀Cl₂O₂

Base Information

• Chemical Name: C₂₂H₂₀Cl₂O₂
• CAS No.: 170651-98-6
• Molecular Formula: C₂₂H₂₀Cl₂O₂
• Molecular Weight: 387.306
• Mol file: 170651-98-6.mol

Synonyms:C₂₂H₂₀Cl₂O₂

Chemical Property of C₂₂H₂₀Cl₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₀Cl₂O₂

There total 4 articles about C₂₂H₂₀Cl₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

[1,4-phenylene-bis(methyleneoxy-4,1-phenylene)]dimethanol (170651-96-4) → C22H20Cl2O2 (170651-98-6)

Guidance literature:

With pyridine; thionyl chloride; In dichloromethane; for 12h; Ambient temperature;

DOI:10.1080/00397919508011438 DOI:10.1021/jo950957y

Reference yield:

1,4-bis(bromomethyl)benzene (623-24-5) → C22H20Cl2O2 (170651-98-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / K₂CO₃ / dimethylformamide / 48 h / 60 °C

2: 90 percent / LiAlH₄ / tetrahydrofuran / 6 h / Heating

3: 90 percent / thionyl chloride, pyridine / CH₂Cl₂ / 12 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo950957y

Reference yield:

1,4-bis-(p-carbomethoxy-phenoxymethyl)-benzene (4204-63-1) → C22H20Cl2O2 (170651-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / LiAlH₄ / tetrahydrofuran / 6 h / Heating

2: 90 percent / thionyl chloride, pyridine / CH₂Cl₂ / 12 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo950957y

upstream raw materials:

[1,4-phenylene-bis(methyleneoxy-4,1-phenylene)]dimethanol

1,4-bis(bromomethyl)benzene

1,4-bis-(p-carbomethoxy-phenoxymethyl)-benzene

methyl 4-hydroxylbenzoate

Downstream raw materials:

{4-[4-(4-Mercaptomethyl-phenoxymethyl)-benzyloxy]-phenyl}-methanethiol

C₃₈H₃₅NO₆

Refernces

• 1、 Kannan,Rajakumar. "Synthesis and molecular transformations of functionalised cyclophanes with large cavity". . p. 3053 - 3065. Retrieved 2007/10/03.