1H-Pyrrolizine-1-carboxylic acid, 6-ethyl-5-(4-F

Base Information

Chemical Name:1H-Pyrrolizine-1-carboxylic acid, 6-ethyl-5-(4-F
CAS No.:83073-37-4
Molecular Formula:C₁₇H₁₆FNO₃
Molecular Weight:301.317
Hs Code.:
ChEMBL ID:CHEMBL355866
DSSTox Substance ID:DTXSID60874906
Nikkaji Number:J1.588.040F

Synonyms:83073-37-4;CHEMBL355866;SCHEMBL10959796;1H-PYRROLIZINE-1-CARBOXYLIC ACID, 6-ETHYL-5-(4-F;DTXSID60874906

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrrolizine-1-carboxylic acid, 6-ethyl-5-(4-F

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:301.11142153
Heavy Atom Count:22
Complexity:447

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1=C(N2CCC(C2=C1)C(=O)O)C(=O)C3=CC=C(C=C3)F

Technology Process of 1H-Pyrrolizine-1-carboxylic acid, 6-ethyl-5-(4-F

There total 3 articles about 1H-Pyrrolizine-1-carboxylic acid, 6-ethyl-5-(4-F which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 107115-66-2
6-Ethyl-5-(4-fluoro-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid isopropyl ester

: 83073-37-4
6-Ethyl-5-(4-fluoro-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

Guidance literature:: With potassium carbonate; In methanol; water; for 1.5h; Heating;
DOI:10.1021/jm00388a013

Reference yield:

: 24167-56-4
N,N-dimethyl-4-fluorobenzamide

: 83073-37-4
6-Ethyl-5-(4-fluoro-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) POCl₃ / 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 1,2-dichloroethane, reflux, 1.5 h

2: 78 percent / K₂CO₃ / methanol; H₂O / 1.5 h / Heating

With potassium carbonate; trichlorophosphate; In methanol; water;
DOI:10.1021/jm00388a013

Reference yield:

: 83820-76-2
isopropyl 1,2-dihydro-6-ethyl-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylate

: 83073-37-4
6-Ethyl-5-(4-fluoro-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) POCl₃ / 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 1,2-dichloroethane, reflux, 1.5 h

2: 78 percent / K₂CO₃ / methanol; H₂O / 1.5 h / Heating

With potassium carbonate; trichlorophosphate; In methanol; water;
DOI:10.1021/jm00388a013