(2R)-1-(4-Chlorophenoxy)-2-propanamine

Base Information

Chemical Name:(2R)-1-(4-Chlorophenoxy)-2-propanamine
CAS No.:545376-15-6
Molecular Formula:C₉H₁₂ClNO
Molecular Weight:185.653
Hs Code.:
DSSTox Substance ID:DTXSID801283213

Synonyms:545376-15-6;DTXSID801283213;AKOS017518193;(2R)-1-(4-Chlorophenoxy)-2-propanamine

Suppliers and Price of (2R)-1-(4-Chlorophenoxy)-2-propanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (2R)-1-(4-Chlorophenoxy)-2-propanamine

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:185.0607417
Heavy Atom Count:12
Complexity:124

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(COC1=CC=C(C=C1)Cl)N
Isomeric SMILES:C[C@H](COC1=CC=C(C=C1)Cl)N

Technology Process of (2R)-1-(4-Chlorophenoxy)-2-propanamine

There total 1 articles about (2R)-1-(4-Chlorophenoxy)-2-propanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 545376-11-2
(+)-(R)-2-phthalimido-1-(4-chlorophenoxy)propane

: 545376-15-6
(R)-2-amino-1-(4-chlorophenoxy)propane

Guidance literature:: With hydrazine hydrate; acetic acid; In methanol; for 7h; Heating;
DOI:10.1021/jm021014d

Reference yield: 89.0%

: 4166-53-4
3-methylglutaric anhydride

: 545376-15-6
(R)-2-amino-1-(4-chlorophenoxy)propane

: 545376-19-0
(R)-1-(4-chlorophenoxy)-2-(4-methyl-2,6-piperidindion-1-yl)propane

Guidance literature:: 3-methylglutaric anhydride; (R)-2-amino-1-(4-chlorophenoxy)propane; In tetrahydrofuran; at 20 ℃;

With acetyl chloride; for 5h; Heating;
DOI:10.1021/jm021014d

Reference yield:

: 545376-15-6
(R)-2-amino-1-(4-chlorophenoxy)propane

: (+)-(R)-4-methyl-1-[2-(4-chlorophenoxy)-1-methyl-ethyl]piperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 20 °C

1.2: 89 percent / acetyl chloride / 5 h / Heating

2.1: borane-methyl sulfide complex / tetrahydrofuran / 4 h / Heating

2.2: aq. HCl / tetrahydrofuran; methanol / 2 h / Heating

With dimethylsulfide borane complex; In tetrahydrofuran;
DOI:10.1021/jm021014d