methyl 5-(3-(difluoromethoxy)-2-nitrophenylamino)thiophene-2-carboxylate

Base Information

Chemical Name:methyl 5-(3-(difluoromethoxy)-2-nitrophenylamino)thiophene-2-carboxylate
CAS No.:1314091-77-4
Molecular Formula:C₁₃H₁₀F₂N₂O₅S
Molecular Weight:344.296
Hs Code.:

Synonyms:methyl 5-(3-(difluoromethoxy)-2-nitrophenylamino)thiophene-2-carboxylate

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Chemical Property of methyl 5-(3-(difluoromethoxy)-2-nitrophenylamino)thiophene-2-carboxylate

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Technology Process of methyl 5-(3-(difluoromethoxy)-2-nitrophenylamino)thiophene-2-carboxylate

There total 4 articles about methyl 5-(3-(difluoromethoxy)-2-nitrophenylamino)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.5%

: 14597-58-1
methyl 5-aminothiophene-2-carboxylate

: C₉H₈BrF₂NO₂

: 1314091-77-4
methyl 5-(3-(difluoromethoxy)-2-nitrophenylamino)thiophene-2-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80 - 90 ℃; for 0.25h; Inert atmosphere;
DOI:10.1021/ml200143c

Reference yield:

: 6317-37-9
5-nitrothiophene-2-carboxylic acid

: 1314091-77-4
methyl 5-(3-(difluoromethoxy)-2-nitrophenylamino)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 1,2-dichloro-ethane / 0.5 h / 150 °C / Microwave irradiation

2: dichloromethane / 0 - 20 °C

3: 20 % Pd(OH)2/C; hydrogen / ethanol

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.25 h / 80 - 90 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; thionyl chloride; 20 % Pd(OH)2/C; hydrogen; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ml200143c

Reference yield:

: 39978-57-9
5-nitrothiophene-2-carbonyl chloride

: 1314091-77-4
methyl 5-(3-(difluoromethoxy)-2-nitrophenylamino)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 0 - 20 °C

2: 20 % Pd(OH)2/C; hydrogen / ethanol

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.25 h / 80 - 90 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 20 % Pd(OH)2/C; hydrogen; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/ml200143c