isopropyl 4-((1R,2S)-2-{2-[4-(cyclopropylcarbonyl)-3,5-difluorophenoxy]ethyl}cyclopropyl)piperidine-1-carboxylate

Base Information

Chemical Name:isopropyl 4-((1R,2S)-2-{2-[4-(cyclopropylcarbonyl)-3,5-difluorophenoxy]ethyl}cyclopropyl)piperidine-1-carboxylate
CAS No.:1402552-32-2
Molecular Formula:C₂₄H₃₁F₂NO₄
Molecular Weight:435.511
Hs Code.:

Synonyms:isopropyl 4-((1R,2S)-2-{2-[4-(cyclopropylcarbonyl)-3,5-difluorophenoxy]ethyl}cyclopropyl)piperidine-1-carboxylate

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Chemical Property of isopropyl 4-((1R,2S)-2-{2-[4-(cyclopropylcarbonyl)-3,5-difluorophenoxy]ethyl}cyclopropyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of isopropyl 4-((1R,2S)-2-{2-[4-(cyclopropylcarbonyl)-3,5-difluorophenoxy]ethyl}cyclopropyl)piperidine-1-carboxylate

There total 12 articles about isopropyl 4-((1R,2S)-2-{2-[4-(cyclopropylcarbonyl)-3,5-difluorophenoxy]ethyl}cyclopropyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402555-07-0
cyclopropyl(2,6-difluoro-4-hydroxyphenyl)methanone

: 1402555-08-1
isopropyl 4-[(1R,2S)-2-(2-hydroxyethyl)cyclopropyl]piperidine-1-carboxylate

: 1402552-32-2
isopropyl 4-((1R,2S)-2-{2-[4-(cyclopropylcarbonyl)-3,5-difluorophenoxy]ethyl}cyclopropyl)piperidine-1-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

Reference yield:

: 287192-97-6
4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester

: 1402552-32-2
isopropyl 4-((1R,2S)-2-{2-[4-(cyclopropylcarbonyl)-3,5-difluorophenoxy]ethyl}cyclopropyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.08 h / -78 °C

1.2: 1 h / -78 °C

2.1: hydrogen; quinoline / Lindlars catalyst / ethyl acetate / 0.67 h

3.1: diethylzinc / dichloromethane; diethyl ether / 0.17 h / -20 °C / Inert atmosphere

3.2: 0.17 h

3.3: 24 h / 0 °C

4.1: hydrogen / palladium(II) hydroxide / ethyl acetate; ethanol / 2585.81 Torr

4.2: 0 °C

4.3: 0.5 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

6.1: caesium carbonate / acetonitrile / 2 h / 20 °C

7.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 °C / Inert atmosphere

With quinoline; hydrogenchloride; n-butyllithium; di-isopropyl azodicarboxylate; hydrogen; diethylzinc; caesium carbonate; triphenylphosphine; palladium(II) hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; hexane; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 1192063-78-7
tert-butyl 4-[(4R)-5-(benzyloxy)-4-hydroxypent-1-yn-1-yl]piperidine-1-carboxylate

: 1402552-32-2
isopropyl 4-((1R,2S)-2-{2-[4-(cyclopropylcarbonyl)-3,5-difluorophenoxy]ethyl}cyclopropyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen; quinoline / Lindlars catalyst / ethyl acetate / 0.67 h

2.1: diethylzinc / dichloromethane; diethyl ether / 0.17 h / -20 °C / Inert atmosphere

2.2: 0.17 h

2.3: 24 h / 0 °C

3.1: hydrogen / palladium(II) hydroxide / ethyl acetate; ethanol / 2585.81 Torr

3.2: 0 °C

3.3: 0.5 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

5.1: caesium carbonate / acetonitrile / 2 h / 20 °C

6.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 °C / Inert atmosphere

With quinoline; hydrogenchloride; di-isopropyl azodicarboxylate; hydrogen; diethylzinc; caesium carbonate; triphenylphosphine; palladium(II) hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; ethyl acetate; acetonitrile;