ethyl 1-(p-methoxy-benzyl)-1,4,5,6-tetrahydro-7-oxo-7H-indole-2-carboxylate

Base Information

Chemical Name:ethyl 1-(p-methoxy-benzyl)-1,4,5,6-tetrahydro-7-oxo-7H-indole-2-carboxylate
CAS No.:1011240-56-4
Molecular Formula:C₁₉H₂₁NO₄
Molecular Weight:327.38
Hs Code.:

Synonyms:ethyl 1-(p-methoxy-benzyl)-1,4,5,6-tetrahydro-7-oxo-7H-indole-2-carboxylate

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Chemical Property of ethyl 1-(p-methoxy-benzyl)-1,4,5,6-tetrahydro-7-oxo-7H-indole-2-carboxylate

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Technology Process of ethyl 1-(p-methoxy-benzyl)-1,4,5,6-tetrahydro-7-oxo-7H-indole-2-carboxylate

There total 4 articles about ethyl 1-(p-methoxy-benzyl)-1,4,5,6-tetrahydro-7-oxo-7H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 2746-25-0
p-Methoxybenzyl bromide

: 119647-73-3
ethyl 7-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate

: 1011240-56-4
ethyl 1-(p-methoxy-benzyl)-1,4,5,6-tetrahydro-7-oxo-7H-indole-2-carboxylate

Guidance literature:: ethyl 7-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate; With 18-crown-6 ether; potassium tert-butylate; In diethyl ether; at 0 ℃; for 0.75h;

p-Methoxybenzyl bromide; In diethyl ether; at 0 - 20 ℃; for 2.75h; Further stages.;
DOI:10.1021/jm0700666

Reference yield: 75.0%

: 824-94-2
p-methoxybenzyl chloride

: 119647-73-3
ethyl 7-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate

: 1011240-56-4
ethyl 1-(p-methoxy-benzyl)-1,4,5,6-tetrahydro-7-oxo-7H-indole-2-carboxylate

Guidance literature:: ethyl 7-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

p-methoxybenzyl chloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.bmc.2010.04.080