(2S,3R,5R)-2-[(1R)-1-(tert-butyldimethylsilyloxy)-6-(4-butylphenyloxy)hexyl]-5-[6-(4-butylphenyloxy)-1-hydroxy-2-hexynyl]-3-(dimethylphenylsilyl)tetrahydrofuran

Base Information

Chemical Name:(2S,3R,5R)-2-[(1R)-1-(tert-butyldimethylsilyloxy)-6-(4-butylphenyloxy)hexyl]-5-[6-(4-butylphenyloxy)-1-hydroxy-2-hexynyl]-3-(dimethylphenylsilyl)tetrahydrofuran
CAS No.:926030-16-2
Molecular Formula:C₅₀H₇₆O₅Si₂
Molecular Weight:813.321
Hs Code.:

(2S,3R,5R)-2-[(1R)-1-(tert-butyldimethylsilyloxy)-6-(4-butylphenyloxy)hexyl]-5-[6-(4-butylphenyloxy)-1-hydroxy-2-hexynyl]-3-(dimethylphenylsilyl)tetrahydrofuran

Synonyms:(2S,3R,5R)-2-[(1R)-1-(tert-butyldimethylsilyloxy)-6-(4-butylphenyloxy)hexyl]-5-[6-(4-butylphenyloxy)-1-hydroxy-2-hexynyl]-3-(dimethylphenylsilyl)tetrahydrofuran

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Chemical Property of (2S,3R,5R)-2-[(1R)-1-(tert-butyldimethylsilyloxy)-6-(4-butylphenyloxy)hexyl]-5-[6-(4-butylphenyloxy)-1-hydroxy-2-hexynyl]-3-(dimethylphenylsilyl)tetrahydrofuran

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Technology Process of (2S,3R,5R)-2-[(1R)-1-(tert-butyldimethylsilyloxy)-6-(4-butylphenyloxy)hexyl]-5-[6-(4-butylphenyloxy)-1-hydroxy-2-hexynyl]-3-(dimethylphenylsilyl)tetrahydrofuran

There total 12 articles about (2S,3R,5R)-2-[(1R)-1-(tert-butyldimethylsilyloxy)-6-(4-butylphenyloxy)hexyl]-5-[6-(4-butylphenyloxy)-1-hydroxy-2-hexynyl]-3-(dimethylphenylsilyl)tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 926030-10-6
5-(4-butylphenyloxy)-1-pentyne

: 926030-15-1
(2R,4R,5S)-5-[(1R)-1-(tert-butyldimethylsilyloxy)-6-(4-butylphenyloxy)hexyl]-4-(dimethylphenylsilyl)tetrahydrofuran-2-carbaldehyde

: 926030-16-2
(2S,3R,5R)-2-[(1R)-1-(tert-butyldimethylsilyloxy)-6-(4-butylphenyloxy)hexyl]-5-[6-(4-butylphenyloxy)-1-hydroxy-2-hexynyl]-3-(dimethylphenylsilyl)tetrahydrofuran

Guidance literature:: 5-(4-butylphenyloxy)-1-pentyne; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

(2R,4R,5S)-5-[(1R)-1-(tert-butyldimethylsilyloxy)-6-(4-butylphenyloxy)hexyl]-4-(dimethylphenylsilyl)tetrahydrofuran-2-carbaldehyde; With cerium(III) chloride; In tetrahydrofuran; hexane; at -78 - -23 ℃; for 3h;
DOI:10.1016/j.tet.2006.11.057

Reference yield:

: 926029-92-7
6-(4-butylphenyloxy)-1-hexanal

: 926030-16-2
(2S,3R,5R)-2-[(1R)-1-(tert-butyldimethylsilyloxy)-6-(4-butylphenyloxy)hexyl]-5-[6-(4-butylphenyloxy)-1-hydroxy-2-hexynyl]-3-(dimethylphenylsilyl)tetrahydrofuran

Guidance literature:: Multi-step reaction with 6 steps

1.1: t-BuOK; n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - -45 °C

1.2: 51 percent / (-)-Ipc₂BOMe; BF₃*Et₂O / tetrahydrofuran; hexane / 4 h / -78 °C

2.1: 98 percent / imidazole / dimethylformamide / 48 h / 50 °C

3.1: 81 percent / SnCl₄; molecular sieves 4 Angstroem / CH₂Cl₂ / 20 h / -45 °C

4.1: 92 percent / hydrogen / Pd(OH)2 on carbon / tetrahydrofuran / 2 h / 20 °C

5.1: 88 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 - 0 °C

6.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

6.2: 74 percent / anhydrous cerium(III) chloride / tetrahydrofuran; hexane / 3 h / -78 - -23 °C

With 1H-imidazole; n-butyllithium; oxalyl dichloride; 4 A molecular sieve; potassium tert-butylate; hydrogen; tin(IV) chloride; dimethyl sulfoxide; triethylamine; palladium hydroxide - carbon; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 5.1: Swern oxidation;
DOI:10.1016/j.tet.2006.11.057

Reference yield:

: 117947-71-4
6-(4-butyl-phenoxy)-hexan-1-ol

: 926030-16-2
(2S,3R,5R)-2-[(1R)-1-(tert-butyldimethylsilyloxy)-6-(4-butylphenyloxy)hexyl]-5-[6-(4-butylphenyloxy)-1-hydroxy-2-hexynyl]-3-(dimethylphenylsilyl)tetrahydrofuran

Guidance literature:: Multi-step reaction with 7 steps

1.1: 84 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 - 0 °C

2.1: t-BuOK; n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - -45 °C

2.2: 51 percent / (-)-Ipc₂BOMe; BF₃*Et₂O / tetrahydrofuran; hexane / 4 h / -78 °C

3.1: 98 percent / imidazole / dimethylformamide / 48 h / 50 °C

4.1: 81 percent / SnCl₄; molecular sieves 4 Angstroem / CH₂Cl₂ / 20 h / -45 °C

5.1: 92 percent / hydrogen / Pd(OH)2 on carbon / tetrahydrofuran / 2 h / 20 °C

6.1: 88 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 - 0 °C

7.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

7.2: 74 percent / anhydrous cerium(III) chloride / tetrahydrofuran; hexane / 3 h / -78 - -23 °C

With 1H-imidazole; n-butyllithium; oxalyl dichloride; 4 A molecular sieve; potassium tert-butylate; hydrogen; tin(IV) chloride; dimethyl sulfoxide; triethylamine; palladium hydroxide - carbon; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 1.1: Swern oxidation / 6.1: Swern oxidation;
DOI:10.1016/j.tet.2006.11.057