4-(2,4-dichlorophenyl)-5-[[4-(4-nitrophenyl)-1-piperazinyl]methyl]-4H-1,2,4,-triazole-3-thiol

Base Information

• Chemical Name: 4-(2,4-dichlorophenyl)-5-[[4-(4-nitrophenyl)-1-piperazinyl]methyl]-4H-1,2,4,-triazole-3-thiol
• CAS No.: 204973-96-6
• Molecular Formula: C₁₉H₁₈Cl₂N₆O₂S
• Molecular Weight: 465.363

Synonyms:4-(2,4-dichlorophenyl)-5-[[4-(4-nitrophenyl)-1-piperazinyl]methyl]-4H-1,2,4,-triazole-3-thiol

Chemical Property of 4-(2,4-dichlorophenyl)-5-[[4-(4-nitrophenyl)-1-piperazinyl]methyl]-4H-1,2,4,-triazole-3-thiol

Chemical Property:

Purity/Quality:

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Technology Process of 4-(2,4-dichlorophenyl)-5-[[4-(4-nitrophenyl)-1-piperazinyl]methyl]-4H-1,2,4,-triazole-3-thiol

There total 2 articles about 4-(2,4-dichlorophenyl)-5-[[4-(4-nitrophenyl)-1-piperazinyl]methyl]-4H-1,2,4,-triazole-3-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(2,4-dichlorophenyl)-1-[4-(4-nitrophenyl)piperazineacetyl]thiosemicarbazide (204973-89-7) → 4-(2,4-dichlorophenyl)-5-[[4-(4-nitrophenyl)-1-piperazinyl]methyl]-4H-1,2,4,-triazole-3-thiol (204973-96-6)

Guidance literature:

With sodium hydroxide; for 8h; Heating;

DOI:10.1111/j.2042-7158.1998.tb03313.x

Reference yield:

2, 4-dichlorophenyl isothiocyanate (6590-96-1) → 4-(2,4-dichlorophenyl)-5-[[4-(4-nitrophenyl)-1-piperazinyl]methyl]-4H-1,2,4,-triazole-3-thiol (204973-96-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / ethanol / 0.5 h / Heating

2: 90 percent / aq. NaOH / 8 h / Heating

With sodium hydroxide; In ethanol; 1: Addition / 2: Cyclization;

DOI:10.1111/j.2042-7158.1998.tb03313.x

Reference yield: 72.0%

2,4-Dichlorobenzyl chloride (94-99-5) + 4-(2,4-dichlorophenyl)-5-[[4-(4-nitrophenyl)-1-piperazinyl]methyl]-4H-1,2,4,-triazole-3-thiol (204973-96-6) → 3-(2,4-dichlorobenzyl)thio-4-(2,4-dichlorophenyl)-5-[[4-(4-nitrophenyl)-1-piperazinyl]methyl]-4H-1,2,4,-triazole

Guidance literature:

With potassium carbonate; In acetone; for 5h; Heating;

DOI:10.1111/j.2042-7158.1998.tb03313.x

upstream raw materials:

4-(2,4-dichlorophenyl)-1-[4-(4-nitrophenyl)piperazineacetyl]thiosemicarbazide

2, 4-dichlorophenyl isothiocyanate

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