(2R)-2-METHYL-1,2-BUTANEDIOL

Base Information

• Chemical Name: (2R)-2-METHYL-1,2-BUTANEDIOL
• CAS No.: 37505-01-4
• Molecular Formula: C₅H₁₂O₂
• Molecular Weight: 104.149
• Mol file: 37505-01-4.mol

Synonyms:1,2-Butanediol,2-methyl-, (R)-; (+)-2-Methyl-1,2-butanediol; (R)(+)-2-Methyl-1,2-butanediol

Chemical Property of (2R)-2-METHYL-1,2-BUTANEDIOL

Chemical Property:

• PSA: 40.46000
• LogP: 0.13970

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R)-2-METHYL-1,2-BUTANEDIOL

There total 10 articles about (2R)-2-METHYL-1,2-BUTANEDIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

menthyl (2'R,3'S)-2',3'-epoxy-2'-methylbutanoate → (R)-(+)-2-methyl-1,3-butandiol (33204-46-5,41051-72-3,94799-23-2,37505-01-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 4h; Heating;

DOI:10.1016/0957-4166(95)00205-4

Reference yield:

(2S,5R)-2-(tert-butyl)-5-ethyl-5-methyl-1,3-dioxolan-4-one (81286-85-3) → (R)-(+)-2-methyl-1,3-butandiol (33204-46-5,41051-72-3,94799-23-2,37505-01-4)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1016/S0040-4020(01)82417-0

Reference yield:

(3S,4R,5S,10S,2'R,3'R)-3-O-[2,3-epoxy-2-methylbutyroyl]cuauhtemone → (R)-(+)-2-methyl-1,3-butandiol (33204-46-5,41051-72-3,94799-23-2,37505-01-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 4h; Heating;

DOI:10.1016/S0957-4166(03)00042-9

upstream raw materials:

methyllithium

(2R/3R)/(2S,3S)-2,3-epoxy-butanol

(2S,5R)-2-(tert-butyl)-5-ethyl-5-methyl-1,3-dioxolan-4-one

Tiglic acid

Downstream raw materials:

C₁₃H₁₈O₃

(3R,E)-3-((4-methoxybenzyl)oxy)-3-methyl-11-((tetrahydro-2H-pyran-2-yl)oxy)undec-9-en-4-ol

C₂₅H₃₈O₅

(R,E)-11-hydroxy-3-((4-methoxybenzyl)oxy)-3-methylundec-9-en-4-one

Refernces

• 1、 Torres-Valencia, J. Martin,Quintero-Mogica, Dora L.,Leon, Guadalupe I.,Suarez-Castillo, Oscar R.,Villagomez-Ibarra, J. Roberto,Maldonado, Emma,Cerda-Garcia-Rojas, Carlos M.,Joseph-Nathan, Pedro. "The absolute configuration of cuauhtemone and related compounds". . p. 543 - 548. Retrieved 2007/10/03.
• 2、 Torres-Valencia, J. Martin,Cerda-Garcia-Rojas, Carlos M.,Joseph-Nathan, Pedro. "Enantioselective preparation of (2R,3R)-(+)- and (2S,3S)-(-)-2,3-epoxy- 2-methylbutanoic acids and some derivatives". . p. 757 - 764. Retrieved 2007/10/03.