C₂₅H₂₇FN₂O₄S

Base Information

• Chemical Name: C₂₅H₂₇FN₂O₄S
• CAS No.: 1287295-89-9
• Molecular Formula: C₂₅H₂₇FN₂O₄S
• Molecular Weight: 470.565
• Mol file: 1287295-89-9.mol

Synonyms:C₂₅H₂₇FN₂O₄S

Chemical Property of C₂₅H₂₇FN₂O₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₂₇FN₂O₄S

There total 4 articles about C₂₅H₂₇FN₂O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H13BrN2 → C25H27FN2O4S (1287295-89-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / water; isopropyl alcohol / 0 - 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / toluene / Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

DOI:10.1016/j.bmcl.2012.01.022

Reference yield:

(4-bromophenyl)hydrazine (589-21-9) → C25H27FN2O4S (1287295-89-9)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / ethanol; water / Reflux

2: potassium carbonate / water; isopropyl alcohol / 0 - 20 °C

3: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / Reflux

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 1: Fischer indole cyclization;

DOI:10.1016/j.bmcl.2012.01.022

Reference yield:

nortropinone (5632-84-8) → C25H27FN2O4S (1287295-89-9)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / ethanol; water / Reflux

2: potassium carbonate / water; isopropyl alcohol / 0 - 20 °C

3: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / Reflux

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 1: Fischer indole cyclization;

DOI:10.1016/j.bmcl.2012.01.022

upstream raw materials:

sodium 3-fluorobenzenesulfinate

C₁₉H₂₃BrN₂O₂

nortropinone

(4-bromophenyl)hydrazine

Downstream raw materials:

C₂₀H₁₉FN₂O₂S*ClH