(R)-3-{(S)-2-[(S)-2-(2-Amino-acetylamino)-6-benzyloxycarbonylamino-hexanoylamino]-3-methyl-butyrylamino}-tetradecanoic acid

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Chemical Name:(R)-3-{(S)-2-[(S)-2-(2-Amino-acetylamino)-6-benzyloxycarbonylamino-hexanoylamino]-3-methyl-butyrylamino}-tetradecanoic acid
CAS No.:172941-89-8
Molecular Formula:C₃₅H₅₉N₅O₇
Molecular Weight:661.883
Hs Code.:

Synonyms:(R)-3-{(S)-2-[(S)-2-(2-Amino-acetylamino)-6-benzyloxycarbonylamino-hexanoylamino]-3-methyl-butyrylamino}-tetradecanoic acid

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Chemical Property of (R)-3-{(S)-2-[(S)-2-(2-Amino-acetylamino)-6-benzyloxycarbonylamino-hexanoylamino]-3-methyl-butyrylamino}-tetradecanoic acid

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Technology Process of (R)-3-{(S)-2-[(S)-2-(2-Amino-acetylamino)-6-benzyloxycarbonylamino-hexanoylamino]-3-methyl-butyrylamino}-tetradecanoic acid

There total 9 articles about (R)-3-{(S)-2-[(S)-2-(2-Amino-acetylamino)-6-benzyloxycarbonylamino-hexanoylamino]-3-methyl-butyrylamino}-tetradecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112-54-9
Dodecanal

: 172941-89-8
(R)-3-{(S)-2-[(S)-2-(2-Amino-acetylamino)-6-benzyloxycarbonylamino-hexanoylamino]-3-methyl-butyrylamino}-tetradecanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / toluene

2: 16 percent

3: hydrogen / Pd(OH)2/C / tetrahydrofuran; H₂O

4: diphenylphosphoryl azide; triethylamine / dimethylformamide

5: trifluoroacetic acid / CH₂Cl₂

6: WSCD*HCl; triethylamine / tetrahydrofuran

7: LiOH / tetrahydrofuran; methanol; H₂O

8: trifluoroacetic acid / CH₂Cl₂

With lithium hydroxide; WSCD*HCl; diphenylphosphoranyl azide; hydrogen; triethylamine; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1: Substitution / 2: Addition / 3: Hydrogenolysis / 4: Condensation / 5: Hydrolysis / 6: Condensation / 7: Hydrolysis / 8: Hydrolysis;
DOI:10.1021/ol005631c

Reference yield:

: 22104-73-0
tetradec-2-enoic acid methyl ester

: 172941-89-8
(R)-3-{(S)-2-[(S)-2-(2-Amino-acetylamino)-6-benzyloxycarbonylamino-hexanoylamino]-3-methyl-butyrylamino}-tetradecanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 16 percent

2: hydrogen / Pd(OH)2/C / tetrahydrofuran; H₂O

3: diphenylphosphoryl azide; triethylamine / dimethylformamide

4: trifluoroacetic acid / CH₂Cl₂

5: WSCD*HCl; triethylamine / tetrahydrofuran

6: LiOH / tetrahydrofuran; methanol; H₂O

7: trifluoroacetic acid / CH₂Cl₂

With lithium hydroxide; WSCD*HCl; diphenylphosphoranyl azide; hydrogen; triethylamine; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Addition / 2: Hydrogenolysis / 3: Condensation / 4: Hydrolysis / 5: Condensation / 6: Hydrolysis / 7: Hydrolysis;
DOI:10.1021/ol005631c

Reference yield:

: 268565-21-5
(R)-3-((R)-1-Phenyl-ethylamino)-tetradecanoic acid methyl ester

: 172941-89-8
(R)-3-{(S)-2-[(S)-2-(2-Amino-acetylamino)-6-benzyloxycarbonylamino-hexanoylamino]-3-methyl-butyrylamino}-tetradecanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen / Pd(OH)2/C / tetrahydrofuran; H₂O

2: diphenylphosphoryl azide; triethylamine / dimethylformamide

3: trifluoroacetic acid / CH₂Cl₂

4: WSCD*HCl; triethylamine / tetrahydrofuran

5: LiOH / tetrahydrofuran; methanol; H₂O

6: trifluoroacetic acid / CH₂Cl₂

With lithium hydroxide; WSCD*HCl; diphenylphosphoranyl azide; hydrogen; triethylamine; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Hydrogenolysis / 2: Condensation / 3: Hydrolysis / 4: Condensation / 5: Hydrolysis / 6: Hydrolysis;
DOI:10.1021/ol005631c