3-Trifluoromethyl-1-(4-methoxyphenyl)-1H-pyrazole

Base Information

Chemical Name:3-Trifluoromethyl-1-(4-methoxyphenyl)-1H-pyrazole
CAS No.:1167437-29-7
Molecular Formula:C₁₁H₉F₃N₂O
Molecular Weight:242.2
Hs Code.:
DSSTox Substance ID:DTXSID501224230

Synonyms:3-Trifluoromethyl-1-(4-methoxyphenyl)-1H-pyrazole;1-(4-methoxyphenyl)-3-(trifluoromethyl)pyrazole;1167437-29-7;SCHEMBL12988881;DTXSID501224230;AKOS015150298;1-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole

Suppliers and Price of 3-Trifluoromethyl-1-(4-methoxyphenyl)-1H-pyrazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Trifluoromethyl-1-(4-methoxyphenyl)-1H-pyrazole

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:242.06669740
Heavy Atom Count:17
Complexity:252

Purity/Quality:

Safty Information:

Pictogram(s):
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MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)N2C=CC(=N2)C(F)(F)F

Technology Process of 3-Trifluoromethyl-1-(4-methoxyphenyl)-1H-pyrazole

There total 1 articles about 3-Trifluoromethyl-1-(4-methoxyphenyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 20154-03-4
3-(trifluoromethyl)pyrazole

: 696-62-8
para-iodoanisole

: 1167437-29-7
3-(trifluoromethyl)-1-(4-methoxyphenyl)-1H-pyrazole

Guidance literature:: With copper(I) oxide; salicylaldehyde-oxime; caesium carbonate; In acetonitrile; for 19.5h; regioselective reaction; Reflux; Inert atmosphere;
DOI:10.1039/b901024f

Reference yield: 98.0%

: 61676-62-8
2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1167437-29-7
3-(trifluoromethyl)-1-(4-methoxyphenyl)-1H-pyrazole

: 1167437-31-1
3-(trifluoromethyl)-1-(4-methoxyphenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Guidance literature:: With CH₃CH₂CH₂CH₂Li; In tetrahydrofuran; hexane; addn. of hexane soln. of butyllithium to THF soln. of boron compd. at -78°C under Ar, stirring at -78°C for 45 min, addn. of boroncompd. at -78°C, stirring for 1.5 h, warming to room temp. over 1 h; addn. of acetic acid, filration through celite, eluting with ethyl acetate, evapn., distillation;
DOI:10.1039/b901024f