(5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methanamine hydrochloride

Base Information

Chemical Name:(5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methanamine hydrochloride
CAS No.:1544662-78-3
Molecular Formula:C₁₉H₁₉F₆NO*ClH
Molecular Weight:427.817
Hs Code.:

Synonyms:(5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methanamine hydrochloride

Suppliers and Price of (5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methanamine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methanamine hydrochloride

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methanamine hydrochloride

There total 7 articles about (5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1544662-71-6
5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthaldehyde

: 1544662-78-3
(5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methanamine hydrochloride

Guidance literature:: 5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthaldehyde; With hydroxylamine hydrochloride; In ethanol; at 20 ℃; for 5h;

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 8h; under 3675.37 Torr;

Reference yield:

: 75091-92-8,75091-93-9,30129-18-1
4-(trifluoromethyl)cyclohexan-1-ol

: 1544662-78-3
(5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methanamine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 85 °C

3.1: ISCO column chromatography / Resolution of racemate

4.1: N-iodo-succinimide; zirconium(IV) chloride / dichloromethane / 20 °C

5.1: N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide / N,N-dimethyl-formamide / 5 h / 85 °C / Inert atmosphere

6.1: hydroxylamine hydrochloride / ethanol / 5 h / 20 °C

6.2: 8 h / 20 °C / 3675.37 Torr

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; copper(l) iodide; hydroxylamine hydrochloride; zirconium(IV) chloride; caesium carbonate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1266120-65-3
4-(trifluoromethyl)cyclohexyl methanesulfonate

: 1544662-78-3
(5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methanamine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 85 °C

2.1: ISCO column chromatography / Resolution of racemate

3.1: N-iodo-succinimide; zirconium(IV) chloride / dichloromethane / 20 °C

4.1: N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide / N,N-dimethyl-formamide / 5 h / 85 °C / Inert atmosphere

5.1: hydroxylamine hydrochloride / ethanol / 5 h / 20 °C

5.2: 8 h / 20 °C / 3675.37 Torr

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; copper(l) iodide; hydroxylamine hydrochloride; zirconium(IV) chloride; caesium carbonate; In ethanol; dichloromethane; N,N-dimethyl-formamide;