4-bromo-2-methylphenethyl 3-cyanophenylcarbamate

Base Information

Chemical Name:4-bromo-2-methylphenethyl 3-cyanophenylcarbamate
CAS No.:943741-03-5
Molecular Formula:C₁₇H₁₅BrN₂O₂
Molecular Weight:359.222
Hs Code.:

Synonyms:4-bromo-2-methylphenethyl 3-cyanophenylcarbamate

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Chemical Property of 4-bromo-2-methylphenethyl 3-cyanophenylcarbamate

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Technology Process of 4-bromo-2-methylphenethyl 3-cyanophenylcarbamate

There total 3 articles about 4-bromo-2-methylphenethyl 3-cyanophenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 16413-26-6
3-cyanophenyl isocyanate

: 943741-03-5
4-bromo-2-methylphenethyl 3-cyanophenylcarbamate

Guidance literature:: 2-(4-bromo-2-methylphenyl)ethanol; With sodium hydride; In tetrahydrofuran; for 0.5h;

3-cyanophenyl isocyanate; In tetrahydrofuran; at -78 ℃; for 2h;

Reference yield:

: 116632-39-4
2-methyl-4-bromoiodobenzene

: 943741-03-5
4-bromo-2-methylphenethyl 3-cyanophenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium fluoride; tetrabutyl-ammonium chloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 0.5 h / 170 °C / Inert atmosphere; Molecular sieve; Microwave irradiation

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0.25 h / 120 °C / Sealed tube; Microwave irradiation

2.2: 0 - 30 °C / Sealed tube

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h

3.2: 2 h / -78 - 20 °C

With potassium fluoride; tetrabutyl-ammonium chloride; sodium hydride; 9-bora-bicyclo[3.3.1]nonane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; toluene; mineral oil;
DOI:10.1021/acs.jmedchem.6b00244

Reference yield:

: 943741-00-2
4-bromo-2-methyl-1-vinylbenzene

: 943741-03-5
4-bromo-2-methylphenethyl 3-cyanophenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0.25 h / 120 °C / Sealed tube; Microwave irradiation

1.2: 0 - 30 °C / Sealed tube

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h

2.2: 2 h / -78 - 20 °C

With sodium hydride; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; mineral oil;
DOI:10.1021/acs.jmedchem.6b00244