(+/-)-1-(4-(7-allyl-7-methyl-4-morpholino-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

Base Information

Chemical Name:(+/-)-1-(4-(7-allyl-7-methyl-4-morpholino-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea
CAS No.:1260089-82-4
Molecular Formula:C₂₃H₂₉N₅O₃
Molecular Weight:423.515
Hs Code.:

Synonyms:(+/-)-1-(4-(7-allyl-7-methyl-4-morpholino-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

Suppliers and Price of (+/-)-1-(4-(7-allyl-7-methyl-4-morpholino-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+/-)-1-(4-(7-allyl-7-methyl-4-morpholino-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+/-)-1-(4-(7-allyl-7-methyl-4-morpholino-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

There total 6 articles about (+/-)-1-(4-(7-allyl-7-methyl-4-morpholino-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 874291-00-6
1-ethyl-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]urea

: 1260089-80-2
(+/-)-7-allyl-2-chloro-7-methyl-4-morpholino-5,7-dihydrofuro[3,4-d]pyrimidine

: 1260089-82-4
(+/-)-1-(4-(7-allyl-7-methyl-4-morpholino-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

Guidance literature:: With potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In water; acetonitrile; at 90 ℃;

Reference yield:

: 1260090-18-3
ethyl 5-allyl-5-methyl-4-oxotetrahydrofuran-3-carboxylate

: 1260089-82-4
(+/-)-1-(4-(7-allyl-7-methyl-4-morpholino-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate / ethanol / 85 °C

2.1: pyridine / 1,2-dichloro-ethane; toluene / 2.17 h / 0 - 20 °C

2.2: 0 - 50 °C

3.1: trichlorophosphate / 1,2-dichloro-ethane / 90 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 0 °C

5.1: potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine / water; acetonitrile / 90 °C

With pyridine; potassium phosphate; ammonium acetate; N-ethyl-N,N-diisopropylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; trichlorophosphate; tricyclohexylphosphine; In ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm200215y

Reference yield:

: 1260090-21-8
(+/-)-ethyl 5-allyl-4-amino-5-methyl-2,5-dihydrofuran-3-carboxylate

: 1260089-82-4
(+/-)-1-(4-(7-allyl-7-methyl-4-morpholino-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 1,2-dichloro-ethane; toluene / 2.17 h / 0 - 20 °C

1.2: 0 - 50 °C

2.1: trichlorophosphate / 1,2-dichloro-ethane / 90 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 0 °C

4.1: potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine / water; acetonitrile / 90 °C

With pyridine; potassium phosphate; N-ethyl-N,N-diisopropylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; trichlorophosphate; tricyclohexylphosphine; In water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm200215y