Synonyms:1,5-benzothiazepine
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The research focuses on an efficient and convenient method for synthesizing 1,5-benzothiazepines and benzodiazepines without the use of solvents. The study employs chalcones as starting materials, reacting them with o-amino thiophenol and o-phenylenediamine in the presence of inorganic supports such as silica gel and alumina. These reactions are carried out at 80°C under solvent-free conditions, resulting in the formation of the desired heterocyclic compounds. The synthesized compounds are characterized using elemental analysis, IR, 1H NMR, and 13C NMR spectroscopy. The research also evaluates the antibacterial activity of the synthesized compounds against pathogens like B. subtilis, E. coli, and S. typhi, revealing that some of the compounds exhibit weak to moderate antibacterial activity. The study highlights the advantages of solvent-free conditions over traditional methods, emphasizing the efficiency and environmental benefits of this approach in the synthesis of these important heterocyclic compounds.
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