N-(4-{5-[(1,4-benzodioxan-2-yl)methylsulfanyl]-1,3,4-oxadiazol-2-yl}phenyl)-3-bromobenzamide

Base Information

• Chemical Name: N-(4-{5-[(1,4-benzodioxan-2-yl)methylsulfanyl]-1,3,4-oxadiazol-2-yl}phenyl)-3-bromobenzamide
• CAS No.: 1608151-08-1
• Molecular Formula: C₂₄H₁₈BrN₃O₄S
• Molecular Weight: 524.395
• Mol file: 1608151-08-1.mol

Synonyms:N-(4-{5-[(1,4-benzodioxan-2-yl)methylsulfanyl]-1,3,4-oxadiazol-2-yl}phenyl)-3-bromobenzamide

Chemical Property of N-(4-{5-[(1,4-benzodioxan-2-yl)methylsulfanyl]-1,3,4-oxadiazol-2-yl}phenyl)-3-bromobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-{5-[(1,4-benzodioxan-2-yl)methylsulfanyl]-1,3,4-oxadiazol-2-yl}phenyl)-3-bromobenzamide

There total 3 articles about N-(4-{5-[(1,4-benzodioxan-2-yl)methylsulfanyl]-1,3,4-oxadiazol-2-yl}phenyl)-3-bromobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-(bromomethyl)-2,3-dihydrobenzo[1,4]dioxine (2164-34-3) + 3-bromo-N-[4-(5-sulfanyl-1,3,4-oxadiazol-2-yl)-phenyl]benzamide (723746-86-9) → N-(4-{5-[(1,4-benzodioxan-2-yl)methylsulfanyl]-1,3,4-oxadiazol-2-yl}phenyl)-3-bromobenzamide (1608151-08-1)

Guidance literature:

3-bromo-N-[4-(5-sulfanyl-1,3,4-oxadiazol-2-yl)-phenyl]benzamide; With potassium hydroxide; In ethanol; at 50 - 60 ℃; for 0.5h;

2-(bromomethyl)-2,3-dihydrobenzo[1,4]dioxine; In ethanol; Reflux;

DOI:10.1134/S1070428014030233

Reference yield:

5-(4-aminophenyl)-1,3,4-oxadiazole-2-thiol (203268-83-1,32058-82-5) → N-(4-{5-[(1,4-benzodioxan-2-yl)methylsulfanyl]-1,3,4-oxadiazol-2-yl}phenyl)-3-bromobenzamide (1608151-08-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / benzene / Reflux

2.1: potassium hydroxide / ethanol / 0.5 h / 50 - 60 °C

2.2: Reflux

With pyridine; potassium hydroxide; In ethanol; benzene;

DOI:10.1134/S1070428014030233

Reference yield:

3-bromobenzoyl chloride (1711-09-7) → N-(4-{5-[(1,4-benzodioxan-2-yl)methylsulfanyl]-1,3,4-oxadiazol-2-yl}phenyl)-3-bromobenzamide (1608151-08-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / benzene / Reflux

2.1: potassium hydroxide / ethanol / 0.5 h / 50 - 60 °C

2.2: Reflux

With pyridine; potassium hydroxide; In ethanol; benzene;

DOI:10.1134/S1070428014030233

upstream raw materials:

5-(4-aminophenyl)-1,3,4-oxadiazole-2-thiol

3-bromobenzoyl chloride

2-(bromomethyl)-2,3-dihydrobenzo[1,4]dioxine

3-bromo-N-[4-(5-sulfanyl-1,3,4-oxadiazol-2-yl)-phenyl]benzamide