(R)-2-<(sec-Butylamino)methyl>-4-nitrophenol

Base Information

• Chemical Name: (R)-2-<(sec-Butylamino)methyl>-4-nitrophenol
• CAS No.: 1071208-73-5
• Molecular Formula: C₁₁H₁₆N₂O₃
• Molecular Weight: 224.26
• Mol file: 1071208-73-5.mol

Synonyms:(R)-2-<(sec-Butylamino)methyl>-4-nitrophenol

Chemical Property of (R)-2-<(sec-Butylamino)methyl>-4-nitrophenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-<(sec-Butylamino)methyl>-4-nitrophenol

There total 1 articles about (R)-2-<(sec-Butylamino)methyl>-4-nitrophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-sec-butylamine (13250-12-9) + 5-Nitrosalicylaldehyde (97-51-8) → (R)-2-<(sec-Butylamino)methyl>-4-nitrophenol (1071208-73-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; 1.) 0 deg C to r.t. over a couple of hours, 2.) r.t., overnight;

DOI:10.1021/jo00002a017

Reference yield: 1.0%

(R)-2-<(sec-Butylamino)methyl>-4-nitrophenol (1071208-73-5) → (R)-<(sec-Butylamino)methyl>-4-aminophenol hydrochloride

Guidance literature:

With formic acid; palladium on activated charcoal; at 90 - 100 ℃; for 2h;

DOI:10.1021/jo00002a017

Reference yield:

(R)-2-<(sec-Butylamino)methyl>-4-nitrophenol (1071208-73-5) → C34H32BrN2O(1+)*BF4(1-)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 percent / 96-98 percent formic acid / 10 percent Pd/C / 2 h / 90 - 100 °C

2: 50 percent / KOH, sodium acetate trihydrate / aq. ethanol / 6 h / Heating

With potassium hydroxide; formic acid; sodium acetate; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo00002a017

upstream raw materials:

(R)-sec-butylamine

5-Nitrosalicylaldehyde