(R)-2-Hydroxy-2-phenylbutyric acid

Base Information

Chemical Name:(R)-2-Hydroxy-2-phenylbutyric acid
CAS No.:3966-31-2
Molecular Formula:C10H12 O3
Molecular Weight:180.203
Hs Code.:2918199090
European Community (EC) Number:622-209-1
DSSTox Substance ID:DTXSID10428377
Nikkaji Number:J74.159K
Wikidata:Q76393792
Mol file:3966-31-2.mol

Synonyms:3966-31-2;(R)-2-HYDROXY-2-PHENYLBUTYRIC ACID;(2R)-2-hydroxy-2-phenylbutanoic acid;(R)-2-Hydroxy-2-phenylbutanoic acid;starbld0001300;SCHEMBL5570579;DTXSID10428377;(?)-alpha-Ethyl-D-mandelic acid;AKOS015891164;(R)-2-Hydroxy-2-phenylbutyric acid,96%

Suppliers and Price of (R)-2-Hydroxy-2-phenylbutyric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(R)-2-HYDROXY-2-PHENYLBUTYRIC ACID 95.00%
1G
$ 728.87

Total 5 raw suppliers

Chemical Property of (R)-2-Hydroxy-2-phenylbutyric acid

Chemical Property:

Melting Point:106-113 °C
Boiling Point:337.8±22.0 °C(Predicted)
PKA:3.52±0.25(Predicted)
PSA：57.53000
Density:1 +-.0.06 g/cm3(Predicted)
LogP:1.36880
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:180.078644241
Heavy Atom Count:13
Complexity:185

Purity/Quality:

98%Min ^*data from raw suppliers

(R)-2-HYDROXY-2-PHENYLBUTYRIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36
Safety Statements: 26

MSDS Files:

Useful:

Canonical SMILES:CCC(C1=CC=CC=C1)(C(=O)O)O
Isomeric SMILES:CC[C@@](C1=CC=CC=C1)(C(=O)O)O

Technology Process of (R)-2-Hydroxy-2-phenylbutyric acid

There total 49 articles about (R)-2-Hydroxy-2-phenylbutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 57133-41-2,57138-98-4,90546-70-6
2-Hydroxy-2-phenyl-butyric acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

: 3966-31-2
(R)-2-hydroxy-2-phenylbutyric acid

: 24256-91-5
(S)-2-hydroxy-2-phenylbutanoic acid

Guidance literature:: With hydroxide; In diethyl ether;
DOI:10.1016/S0040-4039(00)86702-7

Reference yield: 73.0%

: C₁₇H₁₉NO₃

: 3966-31-2
(R)-2-hydroxy-2-phenylbutyric acid

Guidance literature:: With potassium hydroxide; In ethylene glycol; at 150 ℃; for 48h; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.orglett.9b01555

Reference yield: 72.0%

: 15206-55-0
methyl 2-oxo-2-phenylacetate

: 557-20-0
diethylzinc

: 3966-31-2
(R)-2-hydroxy-2-phenylbutyric acid

Guidance literature:: methyl 2-oxo-2-phenylacetate; diethylzinc; chiral salen-based titanium; In toluene; at -40 ℃; for 2h;

With potassium hydroxide; In ethanol;
DOI:10.1016/j.tet.2005.03.117