3-amino-9-benzyl-6-chloro-1-oxo-7,8,9,10-tetrahydro-2H-pyrimido<4,5-c><2,6>naphthyridine hydrochloride

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Chemical Name:3-amino-9-benzyl-6-chloro-1-oxo-7,8,9,10-tetrahydro-2H-pyrimido<4,5-c><2,6>naphthyridine hydrochloride
CAS No.:131010-65-6
Molecular Formula:C₁₇H₁₆ClN₅O*ClH
Molecular Weight:378.261
Hs Code.:

Synonyms:3-amino-9-benzyl-6-chloro-1-oxo-7,8,9,10-tetrahydro-2H-pyrimido<4,5-c><2,6>naphthyridine hydrochloride

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Chemical Property of 3-amino-9-benzyl-6-chloro-1-oxo-7,8,9,10-tetrahydro-2H-pyrimido<4,5-c><2,6>naphthyridine hydrochloride

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Technology Process of 3-amino-9-benzyl-6-chloro-1-oxo-7,8,9,10-tetrahydro-2H-pyrimido<4,5-c><2,6>naphthyridine hydrochloride

There total 2 articles about 3-amino-9-benzyl-6-chloro-1-oxo-7,8,9,10-tetrahydro-2H-pyrimido<4,5-c><2,6>naphthyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 130985-85-2
1,3-diamino-9-benzyl-6-chloro-7,8,9,10-tetrahydropyrimido<4,5-c><2,6>naphthyridine

: 131010-65-6
3-amino-9-benzyl-6-chloro-1-oxo-7,8,9,10-tetrahydro-2H-pyrimido<4,5-c><2,6>naphthyridine hydrochloride

Guidance literature:: With hydrogenchloride; for 1.5h; Heating;
DOI:10.1021/jm00106a022

Reference yield:

: 130985-84-1
1,3-diamino-9-benzyl-7,8,9,10-tetrahydropyrimido<4,5-c><2,6>naphthyridin-6(5H,9H)-one hydrochloride

: 131010-65-6
3-amino-9-benzyl-6-chloro-1-oxo-7,8,9,10-tetrahydro-2H-pyrimido<4,5-c><2,6>naphthyridine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) DMF/SOCl₂, 2.) 50percent EtOH/H₂O / 1.) CHCl₃, reflux, 5 h, 2.) RT 24 h

2: 84 percent / 20percent aq. HCl / 1.5 h / Heating

With hydrogenchloride; thionyl chloride; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00106a022