3-hydroxymethyl-2,2,5,5-tetramethyl-4-phenyl-2,5-dihydro-1H-pyrrol-1-yloxyl radical

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Chemical Name:3-hydroxymethyl-2,2,5,5-tetramethyl-4-phenyl-2,5-dihydro-1H-pyrrol-1-yloxyl radical
CAS No.:215718-94-8
Molecular Formula:C₁₅H₂₀NO₂
Molecular Weight:246.329
Hs Code.:

Synonyms:3-hydroxymethyl-2,2,5,5-tetramethyl-4-phenyl-2,5-dihydro-1H-pyrrol-1-yloxyl radical

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Chemical Property of 3-hydroxymethyl-2,2,5,5-tetramethyl-4-phenyl-2,5-dihydro-1H-pyrrol-1-yloxyl radical

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Technology Process of 3-hydroxymethyl-2,2,5,5-tetramethyl-4-phenyl-2,5-dihydro-1H-pyrrol-1-yloxyl radical

There total 7 articles about 3-hydroxymethyl-2,2,5,5-tetramethyl-4-phenyl-2,5-dihydro-1H-pyrrol-1-yloxyl radical which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 215718-87-9
C₁₇H₂₂NO₃

: 215718-94-8
3-hydroxymethyl-2,2,5,5-tetramethyl-4-phenyl-2,5-dihydro-1H-pyrrol-1-yloxyl radical

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; 1.) -78 deg C, 10 min, 2.) r.t., 1 h;
DOI:10.1055/s-1998-2177

Reference yield: 64.0%

: 85591-93-1
3-bromo-4-hydroxymethyl-2,2,5,5-tetramethyl-Δ³-pyrrolin-1-oxyl

: 98-80-6
phenylboronic acid

: 215718-94-8
3-hydroxymethyl-2,2,5,5-tetramethyl-4-phenyl-2,5-dihydro-1H-pyrrol-1-yloxyl radical

Guidance literature:: With barium dihydroxide; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; Heating;
DOI:10.1055/s-2002-35240

Reference yield:

: 15802-62-7,15802-63-8,620-80-4
(Z)-ethyl 2-benzylidenacetoacetate

: 215718-94-8
3-hydroxymethyl-2,2,5,5-tetramethyl-4-phenyl-2,5-dihydro-1H-pyrrol-1-yloxyl radical

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃, Bu₄HSO₄ / benzene / 0.5 h / 40 °C

2: NH₄Cl, H₂O, Zn / dioxane / 1 h / Ambient temperature

3: NBS, benzoyl peroxide / CCl₄ / 0.08 h / Heating

4: DBU / CCl₄ / 0.5 h / Ambient temperature

5: 2.) MnO₂, O₂ / 1.) Et₂O, THF, r.t., 1 h, 2.) CHCl₃, 30 min

6: 77 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 1.) -78 deg C, 10 min, 2.) r.t., 1 h

With manganese(IV) oxide; N-Bromosuccinimide; Perbenzoic acid; Bu₄HSO₄; water; oxygen; potassium carbonate; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium bis(2-methoxyethoxy)aluminium dihydride; zinc; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; toluene; benzene;
DOI:10.1055/s-1998-2177