Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-fluoro-, (2S)- (9CI)

Base Information

Chemical Name:Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-fluoro-, (2S)- (9CI)
CAS No.:294858-41-6
Molecular Formula:C8H14 F N O4
Molecular Weight:207.202
Hs Code.:
Mol file:294858-41-6.mol

Synonyms:Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-fluoro-, (2S)- (9CI)

Suppliers and Price of Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-fluoro-, (2S)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
(S)-3-((Tert-butoxycarbonyl)amino)-2-fluoropropanoicacid
5g
$ 3435.00

Total 3 raw suppliers

Chemical Property of Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-fluoro-, (2S)- (9CI)

Chemical Property:

PSA：75.63000
LogP:1.32470

Purity/Quality:

99% ^*data from raw suppliers

(S)-3-((Tert-butoxycarbonyl)amino)-2-fluoropropanoicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-fluoro-, (2S)- (9CI)

There total 2 articles about Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-fluoro-, (2S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: (2S)‐3‐{[(tert‐butoxy)carbonyl]amino}‐2‐fluoropropanoic acid methyl ester

: 294858-41-6,412352-68-2
(2S)‐3‐{[(tert‐butoxy)carbonyl]amino}‐2‐fluoropropanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 294858-41-6,412352-68-2
(2S)‐3‐{[(tert‐butoxy)carbonyl]amino}‐2‐fluoropropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 24 percent / i-Pr₂NEt / dioxane / 2 h / 20 °C

2: aq. NaOH / methanol / 1.5 h / 20 °C

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; 1: Acylation / 2: Hydrolysis;
DOI:10.1021/ja000509u

Reference yield: 73.0%

: 2627-86-3
(S)-1-phenyl-ethylamine

: 294858-41-6,412352-68-2
(2S)‐3‐{[(tert‐butoxy)carbonyl]amino}‐2‐fluoropropanoic acid

: [(S)-2-Fluoro-2-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1021/ja000509u