3-(4-BROMOPHENYL)-2-OXOPROPANOIC ACID

Base Information

• Chemical Name: 3-(4-BROMOPHENYL)-2-OXOPROPANOIC ACID
• CAS No.: 38712-59-3
• Molecular Formula: C9H7 Br O3
• Molecular Weight: 243.057
• Hs Code.: 2918300090
• Mol file: 38712-59-3.mol

Synonyms:(4-Bromophenyl)pyruvicacid

Chemical Property of 3-(4-BROMOPHENYL)-2-OXOPROPANOIC ACID

Chemical Property:

• Vapor Pressure: 7.24E-06mmHg at 25°C
• Refractive Index: 1.593
• Boiling Point: 361.8°C at 760 mmHg
• Flash Point: 172.6°C
• PSA: 54.37000
• Density: 1.656g/cm³
• LogP: 1.64530

Purity/Quality:

98%min ^*data from raw suppliers

3-(4-BROMOPHENYL)-2-OXOPROPANOIC ACID 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-BROMOPHENYL)-2-OXOPROPANOIC ACID

There total 9 articles about 3-(4-BROMOPHENYL)-2-OXOPROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-4-(4-bromobenzylidene)-2-methyloxazol-5(4H)-one (1273258-11-9,186605-19-6) → 3-(4-bromophenyl)-2-carbonylpropionic acid (38712-59-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; Reflux;

Reference yield:

4-bromo-benzaldehyde (1122-91-4) → 3-(4-bromophenyl)-2-carbonylpropionic acid (38712-59-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / methanol; diethyl ether / 18 h / 0 - 20 °C

2: hydrogenchloride / water / 0.5 h / 20 °C

3: lithium hydroxide / water

With hydrogenchloride; sodium hydride; lithium hydroxide; In methanol; diethyl ether; water;

DOI:10.1002/ejoc.201201506

Reference yield:

methyl 3-(4-bromophenyl)-2-hydroxyacrylate → 3-(4-bromophenyl)-2-carbonylpropionic acid (38712-59-3)

Guidance literature:

With lithium hydroxide; In water;

DOI:10.1002/ejoc.201201506

upstream raw materials:

3-(4-bromo-phenyl)-3-cyano-2-oxo-propionic acid ethyl ester

2-[(4-Bromo-phenyl)-chloro-methyl]-2-hydroxy-malonic acid

4-Bromophenylacetonitrile

4-bromo-benzaldehyde

Downstream raw materials:

3-(4-bromophenyl)-2-hydroxypropionic acid

C₁₀H₁₁BrO₃

(2R)-3-(4-bromophenyl)-2-hydroxypropanoic acid

H-p-BrPhe-OH

Refernces

• 1、 Zhang, Shiqi,Li, Guangxun,Liu, Hongxin,Wang, Yingwei,Cao, Yuan,Zhao, Gang,Tang, Zhuo. "Bio-inspired enantioselective full transamination using readily available cyclodextrin". . p. 4203 - 4208. Retrieved 2017/02/05.