4-(4-Fluorophenyl)thiophene-2-carbaldehyde

Base Information

• Chemical Name: 4-(4-Fluorophenyl)thiophene-2-carbaldehyde
• CAS No.: 853310-97-1
• Molecular Formula: C₁₁H₇FOS
• Molecular Weight: 206.24
• European Community (EC) Number: 662-209-9
• Mol file: 853310-97-1.mol

Synonyms:4-(4-fluorophenyl)thiophene-2-carbaldehyde;853310-97-1;4-(4-Fluorophenyl)-2-thiophenecarbaldehyde;SCHEMBL2320780;AKOS004116150;EN300-634282;A1-12115

Chemical Property of 4-(4-Fluorophenyl)thiophene-2-carbaldehyde

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 206.02016418
• Heavy Atom Count: 14
• Complexity: 202

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=CSC(=C2)C=O)F

Technology Process of 4-(4-Fluorophenyl)thiophene-2-carbaldehyde

There total 2 articles about 4-(4-Fluorophenyl)thiophene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.1%

4-Bromothiophen-2-aldehyde (18791-75-8) + 4-fluoroboronic acid (1765-93-1) → 4-(4-fluorophenyl)thiophene-2-carbaldehyde (853310-97-1)

Guidance literature:

4-Bromothiophen-2-aldehyde; 4-fluoroboronic acid; With caesium carbonate; In 1,4-dioxane; water; at 20 ℃; for 0.0833333h;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; Inert atmosphere; Reflux;

DOI:10.1016/j.bmcl.2016.03.022

Reference yield:

→ 4-(4-fluorophenyl)thiophene-2-carbaldehyde (853310-97-1)

Guidance literature:

With potassium sulfide; dimethyl sulfoxide; at 140 ℃; for 8h;

Reference yield: 87.0%

4-(4-fluorophenyl)thiophene-2-carbaldehyde (853310-97-1) → 4-(4-fluorophenyl)-2-thiophenemethanol (1019780-55-2)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2007.10.094

upstream raw materials:

4-Bromothiophen-2-aldehyde

4-fluoroboronic acid

Downstream raw materials:

4-(4-fluorophenyl)-2-thiophenemethanol