(2S,4S)-3-oxa-2-butyl-4-<<4-(1-oxa-3-sulfonylbutyl)piperidin-1-yl>carbonyl>-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Base Information

Chemical Name:(2S,4S)-3-oxa-2-butyl-4-<<4-(1-oxa-3-sulfonylbutyl)piperidin-1-yl>carbonyl>-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane
CAS No.:141048-03-5
Molecular Formula:C₃₆H₆₀N₂O₈S
Molecular Weight:680.947
Hs Code.:

(2S,4S)-3-oxa-2-butyl-4-<<4-(1-oxa-3-sulfonylbutyl)piperidin-1-yl>carbonyl>-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Synonyms:(2S,4S)-3-oxa-2-butyl-4-<<4-(1-oxa-3-sulfonylbutyl)piperidin-1-yl>carbonyl>-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

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Chemical Property of (2S,4S)-3-oxa-2-butyl-4-<<4-(1-oxa-3-sulfonylbutyl)piperidin-1-yl>carbonyl>-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

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Technology Process of (2S,4S)-3-oxa-2-butyl-4-<<4-(1-oxa-3-sulfonylbutyl)piperidin-1-yl>carbonyl>-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

There total 8 articles about (2S,4S)-3-oxa-2-butyl-4-<<4-(1-oxa-3-sulfonylbutyl)piperidin-1-yl>carbonyl>-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141048-00-2
(S)-2-[(S)-1-Benzyl-2-(4-methylsulfanylmethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid ((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-amide

: 141048-03-5
(2S,4S)-3-oxa-2-butyl-4-<<4-(1-oxa-3-sulfonylbutyl)piperidin-1-yl>carbonyl>-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 5 ℃; for 0.416667h; Yield given;
DOI:10.1021/jm00088a006

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 141048-03-5
(2S,4S)-3-oxa-2-butyl-4-<<4-(1-oxa-3-sulfonylbutyl)piperidin-1-yl>carbonyl>-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Guidance literature:: Multi-step reaction with 7 steps

1: 16 h / Ambient temperature

2: 21 percent / benzoyl peroxide / acetonitrile / 4 h / 0 °C

3: KOH / H₂O / 24 h / Heating

4: 1.) 1-hydroxybenztriazole hydrate (HOBT), 2.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (EDC) / 1.) DMF, -20 deg C, 2.) DMF, from -20 deg C to RT, overnight

5: 1.) NaH / 1.) THF, DMF, 45 deg C, 3 h, 2.) THF, 45 deg C , 45 min

6: 1.) 1-hydroxybenztriazole (HOBT), N-methylmorpholine, 2.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / 1.) DMF, -23 deg C, 2.) DMF, from -23 deg C to RT, 18 h

7: m-chloroperoxybenzoic acid / CH₂Cl₂ / 0.42 h / 5 °C

With 4-methyl-morpholine; potassium hydroxide; sodium hydride; benzotriazol-1-ol; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; dibenzoyl peroxide; In dichloromethane; water; acetonitrile;
DOI:10.1021/jm00088a006

Reference yield:

: 20312-36-1
L-3-phenyllactic acid

: 141048-03-5
(2S,4S)-3-oxa-2-butyl-4-<<4-(1-oxa-3-sulfonylbutyl)piperidin-1-yl>carbonyl>-5-phenylpentanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 1-hydroxybenztriazole hydrate (HOBT), 2.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (EDC) / 1.) DMF, -20 deg C, 2.) DMF, from -20 deg C to RT, overnight

2: 1.) NaH / 1.) THF, DMF, 45 deg C, 3 h, 2.) THF, 45 deg C , 45 min

3: 1.) 1-hydroxybenztriazole (HOBT), N-methylmorpholine, 2.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / 1.) DMF, -23 deg C, 2.) DMF, from -23 deg C to RT, 18 h

4: m-chloroperoxybenzoic acid / CH₂Cl₂ / 0.42 h / 5 °C

With 4-methyl-morpholine; sodium hydride; benzotriazol-1-ol; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/jm00088a006