4-amino-N,N-bis(3-methylbutyl)-3-[(3-piperidin-1-ylpropyl)amino]benzamide

Base Information

Chemical Name:4-amino-N,N-bis(3-methylbutyl)-3-[(3-piperidin-1-ylpropyl)amino]benzamide
CAS No.:852803-36-2
Molecular Formula:C₂₅H₄₄N₄O
Molecular Weight:416.651
Hs Code.:

Synonyms:4-amino-N,N-bis(3-methylbutyl)-3-[(3-piperidin-1-ylpropyl)amino]benzamide

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Chemical Property of 4-amino-N,N-bis(3-methylbutyl)-3-[(3-piperidin-1-ylpropyl)amino]benzamide

Chemical Property:

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Technology Process of 4-amino-N,N-bis(3-methylbutyl)-3-[(3-piperidin-1-ylpropyl)amino]benzamide

There total 4 articles about 4-amino-N,N-bis(3-methylbutyl)-3-[(3-piperidin-1-ylpropyl)amino]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 746661-91-6
N,N-bis(3-methylbutyl)-4-nitro-3-[(3-piperidin-1-ylpropyl)amino]benzamide

: 852803-36-2
4-amino-N,N-bis(3-methylbutyl)-3-[(3-piperidin-1-ylpropyl)amino]benzamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; for 3h; under 1500.15 Torr;
DOI:10.1016/j.bmcl.2007.06.010

Reference yield:

: 403-21-4
3-fluoro-4-nitrobenzoic acid

: 852803-36-2
4-amino-N,N-bis(3-methylbutyl)-3-[(3-piperidin-1-ylpropyl)amino]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

3: potassium carbonate / acetonitrile / 2.5 h / Reflux

4: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 3 h / 20 °C / 760.05 Torr / Inert atmosphere

With oxalyl dichloride; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In ethanol; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 157665-51-5
3-fluoro-4-nitrobenzoyl chloride

: 852803-36-2
4-amino-N,N-bis(3-methylbutyl)-3-[(3-piperidin-1-ylpropyl)amino]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 2.5 h / Reflux

3: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 3 h / 20 °C / 760.05 Torr / Inert atmosphere

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In ethanol; dichloromethane; ethyl acetate; acetonitrile;