4-fluoro-N-(2-{2-[2-(2-{4-[2,4,6-trioxo-5-(4-phenoxyphenyl)hexahydropyrimidin-5-yl]piperazin-1-yl}ethoxy)ethoxy]ethoxy}ethyl)benzamide

Base Information

Chemical Name:4-fluoro-N-(2-{2-[2-(2-{4-[2,4,6-trioxo-5-(4-phenoxyphenyl)hexahydropyrimidin-5-yl]piperazin-1-yl}ethoxy)ethoxy]ethoxy}ethyl)benzamide
CAS No.:1351556-79-0
Molecular Formula:C₃₅H₄₀FN₅O₈
Molecular Weight:677.73
Hs Code.:

Synonyms:4-fluoro-N-(2-{2-[2-(2-{4-[2,4,6-trioxo-5-(4-phenoxyphenyl)hexahydropyrimidin-5-yl]piperazin-1-yl}ethoxy)ethoxy]ethoxy}ethyl)benzamide

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Chemical Property of 4-fluoro-N-(2-{2-[2-(2-{4-[2,4,6-trioxo-5-(4-phenoxyphenyl)hexahydropyrimidin-5-yl]piperazin-1-yl}ethoxy)ethoxy]ethoxy}ethyl)benzamide

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Technology Process of 4-fluoro-N-(2-{2-[2-(2-{4-[2,4,6-trioxo-5-(4-phenoxyphenyl)hexahydropyrimidin-5-yl]piperazin-1-yl}ethoxy)ethoxy]ethoxy}ethyl)benzamide

There total 3 articles about 4-fluoro-N-(2-{2-[2-(2-{4-[2,4,6-trioxo-5-(4-phenoxyphenyl)hexahydropyrimidin-5-yl]piperazin-1-yl}ethoxy)ethoxy]ethoxy}ethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1024017-23-9
C₂₈H₃₇N₅O₇

: 331987-63-4
1-(4-fluorobenzoyl)pyrrolidine-2,5-dione

: 1351556-79-0
4-fluoro-N-(2-{2-[2-(2-{4-[2,4,6-trioxo-5-(4-phenoxyphenyl)hexahydropyrimidin-5-yl]piperazin-1-yl}ethoxy)ethoxy]ethoxy}ethyl)benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 7.5h;
DOI:10.1021/jm201142w

Reference yield:

: 5-bromo-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione

: 1351556-79-0
4-fluoro-N-(2-{2-[2-(2-{4-[2,4,6-trioxo-5-(4-phenoxyphenyl)hexahydropyrimidin-5-yl]piperazin-1-yl}ethoxy)ethoxy]ethoxy}ethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 5 - 20 °C

2.1: triphenylphosphine / tetrahydrofuran / 16 h / 20 °C

2.2: 3 h / 20 °C

3.1: triethylamine / dichloromethane / 7.5 h / 20 °C

With potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm201142w

Reference yield:

: 219311-20-3
5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione

: 1351556-79-0
4-fluoro-N-(2-{2-[2-(2-{4-[2,4,6-trioxo-5-(4-phenoxyphenyl)hexahydropyrimidin-5-yl]piperazin-1-yl}ethoxy)ethoxy]ethoxy}ethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.33 h / 5 - 10 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 5 - 20 °C

3.1: triphenylphosphine / tetrahydrofuran / 16 h / 20 °C

3.2: 3 h / 20 °C

4.1: triethylamine / dichloromethane / 7.5 h / 20 °C

With N-Bromosuccinimide; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm201142w