tert-butyl-6-(1-cyclohexylethylamino)-5-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-nitro-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-6-oxohexylcarbamate

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Chemical Name:tert-butyl-6-(1-cyclohexylethylamino)-5-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-nitro-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-6-oxohexylcarbamate
CAS No.:1282034-75-6
Molecular Formula:C₅₅H₆₈N₁₂O₁₁
Molecular Weight:1073.22
Hs Code.:

tert-butyl-6-(1-cyclohexylethylamino)-5-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-nitro-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-6-oxohexylcarbamate

Synonyms:tert-butyl-6-(1-cyclohexylethylamino)-5-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-nitro-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-6-oxohexylcarbamate

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Chemical Property of tert-butyl-6-(1-cyclohexylethylamino)-5-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-nitro-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-6-oxohexylcarbamate

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Technology Process of tert-butyl-6-(1-cyclohexylethylamino)-5-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-nitro-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-6-oxohexylcarbamate

There total 5 articles about tert-butyl-6-(1-cyclohexylethylamino)-5-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-nitro-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-6-oxohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1282034-74-5
2-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-nitro-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-6-(tert-butoxycarbonyl)-lysine

: 5913-13-3
[(1R)-1-cyclohexylethyl]amine

: 1282034-75-6
tert-butyl-6-(1-cyclohexylethylamino)-5-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-nitro-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-6-oxohexylcarbamate

Guidance literature:: With 2,6-dimethylpyridine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); 6-chloro-1-hydroxybenzotriazole; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/ja107675n

Reference yield:

: 1282034-71-2
2-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-nitro-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-6-(tert-butoxycarbonyl)-lysine methyl ester

: 1282034-75-6
tert-butyl-6-(1-cyclohexylethylamino)-5-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-nitro-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-6-oxohexylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; water; lithium hydroxide / tetrahydrofuran / 16 h / 65 °C

2: 2,6-dimethylpyridine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); 6-chloro-1-hydroxybenzotriazole / dichloromethane; N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; methanol; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); water; 6-chloro-1-hydroxybenzotriazole; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja107675n

Reference yield:

: 625386-19-8
1-(4-methoxybenzyl)-5-{2-[(4-methoxybenzyl)-5-{[1-(4-methoxybenzyl)-5-nitro-2H-pyrazole-3-carbonyl]pyrazol-3-carbonyl]amino}-2H-pyrazole-3-carbonylamino}-2H-pyrazole-3-carboxylic acid methyl ester

: 1282034-75-6
tert-butyl-6-(1-cyclohexylethylamino)-5-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-(1-(4-methoxybenzyl)-3-nitro-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-1H-pyrazole-5-carboxamido)-6-oxohexylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: methanol; water; lithium hydroxide / tetrahydrofuran / 18 h

2: 2-chloro-1-methyl-pyridinium iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

3: methanol; water; lithium hydroxide / tetrahydrofuran / 16 h / 65 °C

4: 2,6-dimethylpyridine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); 6-chloro-1-hydroxybenzotriazole / dichloromethane; N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; methanol; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); 2-chloro-1-methyl-pyridinium iodide; water; N-ethyl-N,N-diisopropylamine; 6-chloro-1-hydroxybenzotriazole; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja107675n