tert-butyl {2-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

Base Information

Chemical Name:tert-butyl {2-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate
CAS No.:1361318-84-4
Molecular Formula:C₂₇H₂₈ClF₆N₅O₅
Molecular Weight:651.993
Hs Code.:

tert-butyl {2-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

Synonyms:tert-butyl {2-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

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Chemical Property of tert-butyl {2-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

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Technology Process of tert-butyl {2-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

There total 4 articles about tert-butyl {2-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1036474-23-3
tert-butyl N-{2-amino-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

: 959140-61-5
{3-(4-chlorophenyl)-5-oxo-4-[(2,S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

: 1361318-84-4
tert-butyl {2-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1228650-25-6
5-(4-chlorophenyl)-4-[⁽²⁸⁾-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

: 1361318-84-4
tert-butyl {2-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / acetonitrile / 1 h / Reflux

2: chiral silica gel phase based on the selector poly(N-methacryloyl-L-isoleucine-3-pentylamide / 2-Methylpentane; ethyl acetate / Resolution of racemate

3: water; lithium hydroxide / methanol / 1 h / 20 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

With water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; lithium hydroxide; In methanol; 2-Methylpentane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 959140-59-1
methyl {3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetate

: 1361318-84-4
tert-butyl {2-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / methanol / 1 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In methanol; N,N-dimethyl-formamide;