(1S,4R)-2-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)-3-methoxyphenyl)-2-azabicyclo[2.2.1]heptan-3-one

Base Information

Chemical Name:(1S,4R)-2-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)-3-methoxyphenyl)-2-azabicyclo[2.2.1]heptan-3-one
CAS No.:1311236-41-5
Molecular Formula:C₂₄H₂₄ClN₃O₄
Molecular Weight:453.925
Hs Code.:

Synonyms:(1S,4R)-2-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)-3-methoxyphenyl)-2-azabicyclo[2.2.1]heptan-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,4R)-2-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)-3-methoxyphenyl)-2-azabicyclo[2.2.1]heptan-3-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1S,4R)-2-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)-3-methoxyphenyl)-2-azabicyclo[2.2.1]heptan-3-one

There total 5 articles about (1S,4R)-2-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)-3-methoxyphenyl)-2-azabicyclo[2.2.1]heptan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1035216-81-9,1035218-35-9
(Z)-3-chloro-N'-hydroxy-4-isopropoxybenzimidamide

: 1311258-56-6
2-methoxy-4-((1S,4R)-3-oxo-2-azabicyclo[2.2.1]hept-2-yl)benzoic acid

: 1311236-41-5
(1S,4R)-2-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)-3-methoxyphenyl)-2-azabicyclo[2.2.1]heptan-3-one

Guidance literature:: 2-methoxy-4-((1S,4R)-3-oxo-2-azabicyclo[2.2.1]hept-2-yl)benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

(Z)-3-chloro-N'-hydroxy-4-isopropoxybenzimidamide; In N,N-dimethyl-formamide; at 140 ℃; for 4h; Inert atmosphere;

Reference yield:

: 148490-97-5
4-iodo-2-methoxybenzoic acid-methyl ester

: 1311236-41-5
(1S,4R)-2-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)-3-methoxyphenyl)-2-azabicyclo[2.2.1]heptan-3-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate / copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 18 h / 110 °C / Inert atmosphere

2.1: hydrogen / palladium on activated charcoal / ethyl acetate / 6 h / 20 °C

3.1: water; barium(II) hydroxide / ethanol / 16 h / 20 °C / Inert atmosphere

3.2: pH 5 / Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

4.2: 4 h / 140 °C / Inert atmosphere

With potassium phosphate; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; barium(II) hydroxide; copper(l) iodide; palladium on activated charcoal; N,N`-dimethylethylenediamine; In ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 89942-34-7
2-methoxy-4-iodobenzoic acid

: 1311236-41-5
(1S,4R)-2-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)-3-methoxyphenyl)-2-azabicyclo[2.2.1]heptan-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 18 h / 0 - 20 °C / Inert atmosphere

2.1: potassium phosphate / copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 18 h / 110 °C / Inert atmosphere

3.1: hydrogen / palladium on activated charcoal / ethyl acetate / 6 h / 20 °C

4.1: water; barium(II) hydroxide / ethanol / 16 h / 20 °C / Inert atmosphere

4.2: pH 5 / Inert atmosphere

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

5.2: 4 h / 140 °C / Inert atmosphere

With potassium phosphate; thionyl chloride; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; barium(II) hydroxide; copper(l) iodide; palladium on activated charcoal; N,N`-dimethylethylenediamine; In ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;