4-(4-chloro-2-fluoroanilino)-7-methoxy-6-trifluoromethylsulphonyloxyquinoline

Base Information

Chemical Name:4-(4-chloro-2-fluoroanilino)-7-methoxy-6-trifluoromethylsulphonyloxyquinoline
CAS No.:205447-86-5
Molecular Formula:C₁₇H₁₁ClF₄N₂O₄S
Molecular Weight:450.798
Hs Code.:

Synonyms:4-(4-chloro-2-fluoroanilino)-7-methoxy-6-trifluoromethylsulphonyloxyquinoline

Suppliers and Price of 4-(4-chloro-2-fluoroanilino)-7-methoxy-6-trifluoromethylsulphonyloxyquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-chloro-2-fluoroanilino)-7-methoxy-6-trifluoromethylsulphonyloxyquinoline

Chemical Property:

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Technology Process of 4-(4-chloro-2-fluoroanilino)-7-methoxy-6-trifluoromethylsulphonyloxyquinoline

There total 1 articles about 4-(4-chloro-2-fluoroanilino)-7-methoxy-6-trifluoromethylsulphonyloxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 205448-75-5
4-(4-chloro-2-fluoroanilino)-6-hydroxy-7-methoxyquinoline

: 358-23-6
trifluoromethylsulfonic anhydride

: 205447-86-5
4-(4-chloro-2-fluoroanilino)-7-methoxy-6-trifluoromethylsulphonyloxyquinoline

Guidance literature:: With pyridine; at 0 - 20 ℃;

Reference yield: 43.0%

: 205447-86-5
4-(4-chloro-2-fluoroanilino)-7-methoxy-6-trifluoromethylsulphonyloxyquinoline

: 6482-24-2
2-Bromoethyl methyl ether

: 205447-88-7
4-(4-chloro-2-fluoroanilino)-7-methoxy-6-(2-methoxyethylthio)quinoline

Guidance literature:: 4-(4-chloro-2-fluoroanilino)-7-methoxy-6-trifluoromethylsulphonyloxyquinoline; With sodium triisopropylsilanethiolate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; toluene; for 3h; Heating / reflux;

2-Bromoethyl methyl ether; With tetrabutyl ammonium fluoride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); toluene; at 20 ℃; for 1h;