3-(3-Phenyl-ureido)-4,5-dihydro-thiophene-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 3-(3-Phenyl-ureido)-4,5-dihydro-thiophene-2-carboxylic acid methyl ester
• CAS No.: 167280-94-6
• Molecular Formula: C₁₃H₁₄N₂O₃S
• Molecular Weight: 278.332
• Mol file: 167280-94-6.mol

Synonyms:3-(3-Phenyl-ureido)-4,5-dihydro-thiophene-2-carboxylic acid methyl ester

Chemical Property of 3-(3-Phenyl-ureido)-4,5-dihydro-thiophene-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-(3-Phenyl-ureido)-4,5-dihydro-thiophene-2-carboxylic acid methyl ester

There total 1 articles about 3-(3-Phenyl-ureido)-4,5-dihydro-thiophene-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

phenyl isocyanate (103-71-9) + methyl 3-amino-4,5-dihydrothiophene-2-carboxylate (167280-87-7) → 3-(3-Phenyl-ureido)-4,5-dihydro-thiophene-2-carboxylic acid methyl ester (167280-94-6)

Guidance literature:

In toluene; for 12h; Ambient temperature;

DOI:10.1021/jo00110a057

Reference yield: 87.0%

3-(3-Phenyl-ureido)-4,5-dihydro-thiophene-2-carboxylic acid methyl ester (167280-94-6) → 3-Phenyl-6,7-dihydro-1H-thieno[3,2-d]pyrimidine-2,4-dione (167280-96-8)

Guidance literature:

With sodium hydroxide; for 0.5h; Heating;

DOI:10.1021/jo00110a057

Reference yield:

3-(3-Phenyl-ureido)-4,5-dihydro-thiophene-2-carboxylic acid methyl ester (167280-94-6) → 5-Benzylsulfanyl-3-phenyl-6-vinyl-1H-pyrimidine-2,4-dione

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / aq. NaOH / 0.5 h / Heating

2: 80 percent / 1 N aq. NaOH / 24 h / Ambient temperature

With sodium hydroxide;

DOI:10.1021/jo00110a057

upstream raw materials:

phenyl isocyanate

methyl 3-amino-4,5-dihydrothiophene-2-carboxylate

Downstream raw materials:

3-Phenyl-6,7-dihydro-1H-thieno[3,2-d]pyrimidine-2,4-dione