6-(4-benzyl-1-piperazinylcarbonyl)-3-methyl-2,4(1H,3H)-quinazolinedione

Base Information

Chemical Name:6-(4-benzyl-1-piperazinylcarbonyl)-3-methyl-2,4(1H,3H)-quinazolinedione
CAS No.:118621-06-0
Molecular Formula:C₂₁H₂₂N₄O₃
Molecular Weight:378.431
Hs Code.:

Synonyms:6-(4-benzyl-1-piperazinylcarbonyl)-3-methyl-2,4(1H,3H)-quinazolinedione

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Chemical Property of 6-(4-benzyl-1-piperazinylcarbonyl)-3-methyl-2,4(1H,3H)-quinazolinedione

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Technology Process of 6-(4-benzyl-1-piperazinylcarbonyl)-3-methyl-2,4(1H,3H)-quinazolinedione

There total 4 articles about 6-(4-benzyl-1-piperazinylcarbonyl)-3-methyl-2,4(1H,3H)-quinazolinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 2759-28-6
1-phenylmethylpiperazine

: 118621-02-6
2,4-dioxo-3-methyl-1,2,3,4-tetrahydroquinazoline-6-carboxylic acid

: 118621-06-0
6-(4-benzyl-1-piperazinylcarbonyl)-3-methyl-2,4(1H,3H)-quinazolinedione

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; 1.) 0-5 deg C, 30 min; 2.) rt, 1.5 h;
DOI:10.1248/cpb.36.2253

Reference yield:

: 63746-12-3
dimethyl 4-aminoisophthalate

: 118621-06-0
6-(4-benzyl-1-piperazinylcarbonyl)-3-methyl-2,4(1H,3H)-quinazolinedione

Guidance literature:: Multi-step reaction with 4 steps

1: acetone / 6 h / 70 - 80 °C

2: sodium ethoxide / ethanol / 2 h / Heating

3: 83 percent / aq. NaOH; methanol / 1.5 h / Heating

4: 93 percent / diethyl phosphorocyanidate, triethylamine / dimethylformamide / 1.) 0-5 deg C, 30 min; 2.) rt, 1.5 h

With diethyl cyanophosphonate; sodium ethanolate; triethylamine; In methanol; sodium hydroxide; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.36.2253

Reference yield:

: 118621-01-5
methyl 2,4-dioxo-3-methyl-1,2,3,4-tetrahydroquinazoline-6-carboxylate

: 118621-06-0
6-(4-benzyl-1-piperazinylcarbonyl)-3-methyl-2,4(1H,3H)-quinazolinedione

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / aq. NaOH; methanol / 1.5 h / Heating

2: 93 percent / diethyl phosphorocyanidate, triethylamine / dimethylformamide / 1.) 0-5 deg C, 30 min; 2.) rt, 1.5 h

With diethyl cyanophosphonate; triethylamine; In methanol; sodium hydroxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.2253