2-<<(benzyloxy)carbonyl>methylamino>-1-(methoxymethoxy)ethane

Base Information

• Chemical Name: 2-<<(benzyloxy)carbonyl>methylamino>-1-(methoxymethoxy)ethane
• CAS No.: 122225-41-6
• Molecular Formula: C₁₃H₁₉NO₄
• Molecular Weight: 253.298
• Mol file: 122225-41-6.mol

Synonyms:2-<<(benzyloxy)carbonyl>methylamino>-1-(methoxymethoxy)ethane

Chemical Property of 2-<<(benzyloxy)carbonyl>methylamino>-1-(methoxymethoxy)ethane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-<<(benzyloxy)carbonyl>methylamino>-1-(methoxymethoxy)ethane

There total 1 articles about 2-<<(benzyloxy)carbonyl>methylamino>-1-(methoxymethoxy)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzyl (2-hydroxyethyl)methylcarbamate (67580-96-5) + chloromethyl methyl ether (107-30-2) → 2-<<(benzyloxy)carbonyl>methylamino>-1-(methoxymethoxy)ethane (122225-41-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1021/jm00169a024

Reference yield:

2-<<(benzyloxy)carbonyl>methylamino>-1-(methoxymethoxy)ethane (122225-41-6) → (2R)-2-benzyl-3-<<<2-(methoxymethoxy)ethyl>methylamino>carbonyl>propionic acid (127944-67-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / H₂ / 10percent Pd/C / methanol / 12 h

2: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) CH₂Cl₂, -10 deg C, 3 min, 2a.) -10 deg, 15 min, 2b.) RT, 2 h

3: 100 percent / H₂ / 10percent Pd/C / methanol / 1 h

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00169a024

Reference yield:

2-<<(benzyloxy)carbonyl>methylamino>-1-(methoxymethoxy)ethane (122225-41-6) → <<<2-(methoxymethoxy)ethyl>methylamino>carbonyl>-O-methyltyrosine (122225-50-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / H₂ / 10percent Pd/C / methanol / 12 h

2: 58 percent / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) RT, overnight

3: 100 percent / aq. LiOH / dioxane / 1 h / 0 °C

With lithium hydroxide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.1021/jm00169a024

upstream raw materials:

benzyl (2-hydroxyethyl)methylcarbamate

chloromethyl methyl ether

Downstream raw materials:

(2R)-2-benzyl-3-<<<2-(methoxymethoxy)ethyl>methylamino>carbonyl>propionic acid

<<<2-(methoxymethoxy)ethyl>methylamino>carbonyl>-O-methyltyrosine

<<<2-(methoxymethoxy)ethyl>methylamino>carbonyl>-O-methyltyrosine methyl ester

benzyl (2R)-2-benzyl-3-<<<2-(methoxymethoxy)ethyl>methylamino>carbonyl>propionate