N²-[1-(4-bromophenyl)-2,2,2-trifluoroethyl]-N¹-(cyanomethyl)-L-leucinamide

Base Information

Chemical Name:N²-[1-(4-bromophenyl)-2,2,2-trifluoroethyl]-N¹-(cyanomethyl)-L-leucinamide
CAS No.:603139-06-6
Molecular Formula:C₁₆H₁₉BrF₃N₃O
Molecular Weight:406.246
Hs Code.:

N<sup>2</sup>-[1-(4-bromophenyl)-2,2,2-trifluoroethyl]-N<sup>1</sup>-(cyanomethyl)-L-leucinamide

Synonyms:N²-[1-(4-bromophenyl)-2,2,2-trifluoroethyl]-N¹-(cyanomethyl)-L-leucinamide

Suppliers and Price of N²-[1-(4-bromophenyl)-2,2,2-trifluoroethyl]-N¹-(cyanomethyl)-L-leucinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N²-[1-(4-bromophenyl)-2,2,2-trifluoroethyl]-N¹-(cyanomethyl)-L-leucinamide

Chemical Property:

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Technology Process of N²-[1-(4-bromophenyl)-2,2,2-trifluoroethyl]-N¹-(cyanomethyl)-L-leucinamide

There total 6 articles about N²-[1-(4-bromophenyl)-2,2,2-trifluoroethyl]-N¹-(cyanomethyl)-L-leucinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 867011-60-7
(2S)-2-[1-(4-bromo-phenyl)-2,2,2-trifluoro-ethylamino]-4-methyl-pentan-1-ol

: 603139-06-6
N²-[1-(4-bromophenyl)-2,2,2-trifluoroethyl]-N¹-(cyanomethyl)-L-leucinamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₅IO₆; CrO₃ / acetonitrile / 2 h

2: PyBOP; Et₃N / dimethylformamide / 14 h

With chromium(VI) oxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; periodic acid; triethylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2005.07.071

Reference yield:

: 7533-40-6,14438-11-0
(S)-2-amino-4-methylpentan-1-ol

: 603139-06-6
N²-[1-(4-bromophenyl)-2,2,2-trifluoroethyl]-N¹-(cyanomethyl)-L-leucinamide

Guidance literature:: Multi-step reaction with 4 steps

1: benzene / 18 h

2: tetrahydrofuran / 1 h / 0 °C

3: H₅IO₆; CrO₃ / acetonitrile / 2 h

4: PyBOP; Et₃N / dimethylformamide / 14 h

With chromium(VI) oxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; periodic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1016/j.bmcl.2005.07.071

Reference yield:

: 18620-02-5
(4-bromophenyl)magnesium bromide

: 603139-06-6
N²-[1-(4-bromophenyl)-2,2,2-trifluoroethyl]-N¹-(cyanomethyl)-L-leucinamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 1 h / 0 °C

2: H₅IO₆; CrO₃ / acetonitrile / 2 h

3: PyBOP; Et₃N / dimethylformamide / 14 h

With chromium(VI) oxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; periodic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2005.07.071