Technology Process of 2-cyclobutyloxy-N-(2-methanesulfonylaminocarbonyl-indan-2-yl)-3-methyl-benzamide
There total 9 articles about 2-cyclobutyloxy-N-(2-methanesulfonylaminocarbonyl-indan-2-yl)-3-methyl-benzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
for 144h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: caesium carbonate / potassium iodide / N,N-dimethyl-formamide / 96 h / 43 °C
2.1: methanol; lithium hydroxide; water / 1,4-dioxane / 18 h
2.2: pH 2
3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h
3.2: 288 h
4.1: methanol; lithium hydroxide; water / 1,4-dioxane / 20 h
4.2: pH 2
5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 144 h
With
methanol; dmap; lithium hydroxide; water; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
potassium iodide;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / acetonitrile / 75 °C
2.1: hydrogenchloride; water / ethanol / 5 h / 20 °C
2.2: pH 10
3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h
3.2: 288 h
4.1: methanol; lithium hydroxide; water / 1,4-dioxane / 20 h
4.2: pH 2
5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 144 h
With
hydrogenchloride; methanol; dmap; lithium hydroxide; water; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
