methyl N-(tert-butoxycarbonyl)-4-(3-methyl-2,6-dioxo-3,6-dihydropyrimidine-1(2H)-yl)-L-phenylalaninate

Base Information

Chemical Name:methyl N-(tert-butoxycarbonyl)-4-(3-methyl-2,6-dioxo-3,6-dihydropyrimidine-1(2H)-yl)-L-phenylalaninate
CAS No.:401906-12-5
Molecular Formula:C₂₀H₂₅N₃O₆
Molecular Weight:403.435
Hs Code.:

Synonyms:methyl N-(tert-butoxycarbonyl)-4-(3-methyl-2,6-dioxo-3,6-dihydropyrimidine-1(2H)-yl)-L-phenylalaninate

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Chemical Property of methyl N-(tert-butoxycarbonyl)-4-(3-methyl-2,6-dioxo-3,6-dihydropyrimidine-1(2H)-yl)-L-phenylalaninate

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Technology Process of methyl N-(tert-butoxycarbonyl)-4-(3-methyl-2,6-dioxo-3,6-dihydropyrimidine-1(2H)-yl)-L-phenylalaninate

There total 5 articles about methyl N-(tert-butoxycarbonyl)-4-(3-methyl-2,6-dioxo-3,6-dihydropyrimidine-1(2H)-yl)-L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 615-77-0
1-methyluracil

: 224824-22-0
(S)-(4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)phenyl)boronic acid

: 401906-12-5
methyl N-(tert-butoxycarbonyl)-4-(3-methyl-2,6-dioxo-3,6-dihydropyrimidine-1(2H)-yl)-L-phenylalaninate

Guidance literature:: With copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 60h;

Reference yield:

: 401906-13-6
(2S)-2-(t-butoxycarbonylamino)-3-[4-(1-methyluracil-3-yl)phenyl] propionic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: 401906-12-5
methyl N-(tert-butoxycarbonyl)-4-(3-methyl-2,6-dioxo-3,6-dihydropyrimidine-1(2H)-yl)-L-phenylalaninate

Guidance literature:: In ethanol; hexane;

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 401906-12-5
methyl N-(tert-butoxycarbonyl)-4-(3-methyl-2,6-dioxo-3,6-dihydropyrimidine-1(2H)-yl)-L-phenylalaninate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 12 h / 95 °C

3: water; sodium periodate; ammonium acetate / acetone / 55 h / 20 °C

4: copper diacetate; triethylamine / dichloromethane / 60 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium periodate; ammonium acetate; water; potassium acetate; copper diacetate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;