2-Benzyl-1-methylpiperazine

Base Information

Chemical Name:2-Benzyl-1-methylpiperazine
CAS No.:290832-49-4
Molecular Formula:C₁₂H₁₈N₂
Molecular Weight:190.288
Hs Code.:
European Community (EC) Number:843-120-6
DSSTox Substance ID:DTXSID20595423
Mol file:290832-49-4.mol

Synonyms:2-benzyl-1-methylpiperazine;1263481-99-7;1-Methyl-2-(phenylmethyl)piperazine;SCHEMBL22285003;DTXSID20595423;AKOS014174985;1-Methyl-2-(phenylmethyl)piperazine 2HCl;EN300-206100

Suppliers and Price of 2-Benzyl-1-methylpiperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-Benzyl-1-methylpiperazine

Chemical Property:

PSA：15.27000
LogP:1.39940
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:190.146998583
Heavy Atom Count:14
Complexity:164

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCNCC1CC2=CC=CC=C2

Technology Process of 2-Benzyl-1-methylpiperazine

There total 4 articles about 2-Benzyl-1-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: (6S)-1-methyl-6-(phenylmethyl)-2,5-piperazinedione

: 290832-49-4
(2S)-1-methyl-2-(phenylmethyl)piperazine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 1h; Reflux;

Reference yield:

: 102185-45-5
N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-phenylalanine dicyclohexylamine salt

: 290832-49-4
(2S)-1-methyl-2-(phenylmethyl)piperazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / dichloromethane; water

1.2: 0.17 h / 0 °C

1.3: 3 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

3.1: toluene / 42 h / 170 °C / Sealed tube

4.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 °C / Reflux

With hydrogenchloride; lithium aluminium tetrahydride; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene;

Reference yield:

: (S)-N-(2-{N-[(1,1-dimethylethoxy)carbonyl](methyl)amino}-1-oxo-3-phenylpropyl)glycine methyl ester

: 290832-49-4
(2S)-1-methyl-2-(phenylmethyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

2: toluene / 42 h / 170 °C / Sealed tube

3: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 1 h / 0 °C / Reflux

With lithium aluminium tetrahydride; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;