diethyl 2-desamino-2-methyl-N¹-(trifluoroacetyl)-5,8-dideaza-1,2-dihydrofolate

Base Information

Chemical Name:diethyl 2-desamino-2-methyl-N¹-(trifluoroacetyl)-5,8-dideaza-1,2-dihydrofolate
CAS No.:133933-32-1
Molecular Formula:C₃₁H₃₃F₃N₄O₇
Molecular Weight:630.621
Hs Code.:

diethyl 2-desamino-2-methyl-N<sup>1</sup>-(trifluoroacetyl)-5,8-dideaza-1,2-dihydrofolate

Synonyms:diethyl 2-desamino-2-methyl-N¹-(trifluoroacetyl)-5,8-dideaza-1,2-dihydrofolate

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Chemical Property of diethyl 2-desamino-2-methyl-N¹-(trifluoroacetyl)-5,8-dideaza-1,2-dihydrofolate

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Technology Process of diethyl 2-desamino-2-methyl-N¹-(trifluoroacetyl)-5,8-dideaza-1,2-dihydrofolate

There total 4 articles about diethyl 2-desamino-2-methyl-N¹-(trifluoroacetyl)-5,8-dideaza-1,2-dihydrofolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 76858-72-5
diethyl N-(4-(prop-2-ynylamino)benzoyl)-L-glutamate

: 133933-31-0
6-(bromomethyl)-2-methyl-1-(trifluoroacetyl)-1,2,3,4-tetrahydroquinazolin-4-one

: 133933-32-1
diethyl 2-desamino-2-methyl-N¹-(trifluoroacetyl)-5,8-dideaza-1,2-dihydrofolate

Guidance literature:: With magnesium oxide; In N,N-dimethyl acetamide; at 80 - 90 ℃; for 18h;
DOI:10.1021/jm00113a011

Reference yield:

: 18731-19-6
3,4-dihydro-2,6-dimethyl-4-oxoquinazoline

: 133933-32-1
diethyl 2-desamino-2-methyl-N¹-(trifluoroacetyl)-5,8-dideaza-1,2-dihydrofolate

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / NaBH₄, HOAc / Ambient temperature

2: 65 percent / CH₂Cl₂ / Ambient temperature

3: 72 percent / N-bromosuccinimide (NBS), benzoyl peroxide / CCl₄ / 5 h / Heating; Irradiation

4: 58 percent / MgO / N,N-dimethyl-acetamide / 18 h / 80 - 90 °C

With sodium tetrahydroborate; N-Bromosuccinimide; Perbenzoic acid; magnesium oxide; acetic acid; In tetrachloromethane; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/jm00113a011

Reference yield:

: 133933-29-6
2,6-dimethyl-1,2,3,4-tetrahydroquinazolin-4-one

: 133933-32-1
diethyl 2-desamino-2-methyl-N¹-(trifluoroacetyl)-5,8-dideaza-1,2-dihydrofolate

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / CH₂Cl₂ / Ambient temperature

2: 72 percent / N-bromosuccinimide (NBS), benzoyl peroxide / CCl₄ / 5 h / Heating; Irradiation

3: 58 percent / MgO / N,N-dimethyl-acetamide / 18 h / 80 - 90 °C

With N-Bromosuccinimide; Perbenzoic acid; magnesium oxide; In tetrachloromethane; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/jm00113a011