dimethyl-7-methyl-1-(4-methylphenylsulfonyl)-3-vinyl-2,3-dihydroquinoline-4,4(1H)-dicarboxylate

Base Information

Chemical Name:dimethyl-7-methyl-1-(4-methylphenylsulfonyl)-3-vinyl-2,3-dihydroquinoline-4,4(1H)-dicarboxylate
CAS No.:1257322-14-7
Molecular Formula:C₂₃H₂₅NO₆S
Molecular Weight:443.521
Hs Code.:

Synonyms:dimethyl-7-methyl-1-(4-methylphenylsulfonyl)-3-vinyl-2,3-dihydroquinoline-4,4(1H)-dicarboxylate

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Chemical Property of dimethyl-7-methyl-1-(4-methylphenylsulfonyl)-3-vinyl-2,3-dihydroquinoline-4,4(1H)-dicarboxylate

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Technology Process of dimethyl-7-methyl-1-(4-methylphenylsulfonyl)-3-vinyl-2,3-dihydroquinoline-4,4(1H)-dicarboxylate

There total 5 articles about dimethyl-7-methyl-1-(4-methylphenylsulfonyl)-3-vinyl-2,3-dihydroquinoline-4,4(1H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 25260-60-0
cis-1,4-bis(acetyloxy)but-2-ene

: 1257322-03-4
dimethyl 2-[4-methyl-2-(4-methylphenylsulfonamido)phenyl]malonate

: 1257322-14-7
dimethyl-7-methyl-1-(4-methylphenylsulfonyl)-3-vinyl-2,3-dihydroquinoline-4,4(1H)-dicarboxylate

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,3-bis-(diphenylphosphino)propane; potassium carbonate; In tetrahydrofuran; at 80 ℃; for 2h; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.09.033

Reference yield:

: 481065-78-5
dimethyl 2-(4-methyl-2-nitrophenyl)malonate

: 1257322-14-7
dimethyl-7-methyl-1-(4-methylphenylsulfonyl)-3-vinyl-2,3-dihydroquinoline-4,4(1H)-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; 10% Pd/C / methanol / 2 h / 20 °C / 2660.18 Torr

2: pyridine / dichloromethane / 2 h / 20 °C

3: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,3-bis-(diphenylphosphino)propane; potassium carbonate / tetrahydrofuran / 2.5 h / 20 - 80 °C

With pyridine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 10% Pd/C; 1,3-bis-(diphenylphosphino)propane; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tet.2012.09.075

Reference yield:

: 446-11-7
4-fluoro-3-nitrotoluene

: 1257322-14-7
dimethyl-7-methyl-1-(4-methylphenylsulfonyl)-3-vinyl-2,3-dihydroquinoline-4,4(1H)-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.17 h / 90 °C

1.2: 2 h / 20 - 90 °C

2.1: hydrogen; 10% Pd/C / methanol / 2 h / 20 °C / 2660.18 Torr

3.1: pyridine / dichloromethane / 2 h / 20 °C

4.1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,3-bis-(diphenylphosphino)propane; potassium carbonate / tetrahydrofuran / 2.5 h / 20 - 80 °C

With pyridine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 10% Pd/C; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.09.075