1-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-difluoromethylene-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-difluoromethylene-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
CAS No.:179026-54-1
Molecular Formula:C₃₇H₄₂F₂N₂O₇Si
Molecular Weight:692.832
Hs Code.:

1-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-difluoromethylene-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Synonyms:1-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-difluoromethylene-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Chemical Property of 1-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-difluoromethylene-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Technology Process of 1-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-difluoromethylene-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

There total 2 articles about 1-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-difluoromethylene-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 58310-30-8
bromodifluoromethyl[tris(dimethylamino)]phosphonium bromide

: 179026-52-9
1-[(2R,3S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

: 179026-54-1
1-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-difluoromethylene-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: With zinc; In tetrahydrofuran; for 0.416667h; Heating;
DOI:10.1016/0040-4020(96)00364-X

Reference yield:

: 81246-80-2
5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl uridine

: 179026-54-1
1-[(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-difluoromethylene-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / pyridinium dichromate, 3 Angstroem molecular sieves / CH₂Cl₂ / 18 h / Ambient temperature

2: 69 percent / Zn / tetrahydrofuran / 0.42 h / Heating

With dipyridinium dichromate; 3 A molecular sieve; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1016/0040-4020(96)00364-X