6-(4-methoxyphenyl)-5-methyl-2-(thiophen-2-yl)thieno[2,3-d]pyrimidin-4-ol

Base Information

• Chemical Name: 6-(4-methoxyphenyl)-5-methyl-2-(thiophen-2-yl)thieno[2,3-d]pyrimidin-4-ol
• CAS No.: 949527-58-6
• Molecular Formula: C₁₈H₁₄N₂O₂S₂
• Molecular Weight: 354.453

Synonyms:6-(4-methoxyphenyl)-5-methyl-2-(thiophen-2-yl)thieno[2,3-d]pyrimidin-4-ol

Chemical Property of 6-(4-methoxyphenyl)-5-methyl-2-(thiophen-2-yl)thieno[2,3-d]pyrimidin-4-ol

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Technology Process of 6-(4-methoxyphenyl)-5-methyl-2-(thiophen-2-yl)thieno[2,3-d]pyrimidin-4-ol

There total 2 articles about 6-(4-methoxyphenyl)-5-methyl-2-(thiophen-2-yl)thieno[2,3-d]pyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

thiophene-2-carbonitrile (1003-31-2) + 2-amino-4-methyl-5-(4-methoxyphenyl)thiophene-3-carboxylic acid ethyl ester (165809-38-1) → 6-(4-methoxyphenyl)-5-methyl-2-(thiophen-2-yl)thieno[2,3-d]pyrimidin-4-ol (949527-58-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 110 ℃; for 36h;

DOI:10.1016/j.ejmech.2014.08.001

Reference yield:

4-methoxybenzyl methyl ketone (122-84-9) → 6-(4-methoxyphenyl)-5-methyl-2-(thiophen-2-yl)thieno[2,3-d]pyrimidin-4-ol (949527-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfur; diethylamine / ethanol / 36 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 36 h / 110 °C

With hydrogenchloride; sulfur; diethylamine; In 1,4-dioxane; ethanol;

DOI:10.1016/j.ejmech.2014.08.001

Reference yield: 91.0%

6-(4-methoxyphenyl)-5-methyl-2-(thiophen-2-yl)thieno[2,3-d]pyrimidin-4-ol (949527-58-6) → 4-chloro-6-(4-methoxyphenyl)-5-methyl-2-(thiophen-2-yl)thieno[2,3-d]pyrimidine (949527-59-7)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 3h;

DOI:10.1016/j.ejmech.2014.08.001

upstream raw materials:

thiophene-2-carbonitrile

2-amino-4-methyl-5-(4-methoxyphenyl)thiophene-3-carboxylic acid ethyl ester

4-methoxybenzyl methyl ketone

Downstream raw materials:

4-chloro-6-(4-methoxyphenyl)-5-methyl-2-(thiophen-2-yl)thieno[2,3-d]pyrimidine

C₁₈H₁₆N₄OS₂

4-chloro-6-(4-hydroxyphenyl)-5-methyl-2-(thiophen-2-yl)thieno[2,3-d]pyrimidine

(2-[4-(4-chloro-5-methyl-2-thiophen-2-yl-thieno[2,3-d]pyrimidin-6-yl)-phenoxy]-ethyl)-dimethyl-amine

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