1-(2-(4-(1,3-benzothiazol-2-yl)phenylamino)-2-oxoethyl)-1,4,7-triazacyclononane

Base Information

Chemical Name:1-(2-(4-(1,3-benzothiazol-2-yl)phenylamino)-2-oxoethyl)-1,4,7-triazacyclononane
CAS No.:1430238-18-8
Molecular Formula:C₂₁H₂₅N₅OS
Molecular Weight:395.528
Hs Code.:

Synonyms:1-(2-(4-(1,3-benzothiazol-2-yl)phenylamino)-2-oxoethyl)-1,4,7-triazacyclononane

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Chemical Property of 1-(2-(4-(1,3-benzothiazol-2-yl)phenylamino)-2-oxoethyl)-1,4,7-triazacyclononane

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Technology Process of 1-(2-(4-(1,3-benzothiazol-2-yl)phenylamino)-2-oxoethyl)-1,4,7-triazacyclononane

There total 7 articles about 1-(2-(4-(1,3-benzothiazol-2-yl)phenylamino)-2-oxoethyl)-1,4,7-triazacyclononane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1430238-17-7
1-(2-(4-(1,3-benzothiazol-2-yl)phenylamino)-2-oxoethyl)-4-formyl-1,4,7-triazacyclononane

: 1430238-18-8
1-(2-(4-(1,3-benzothiazol-2-yl)phenylamino)-2-oxoethyl)-1,4,7-triazacyclononane

Guidance literature:: 1-(2-(4-(1,3-benzothiazol-2-yl)phenylamino)-2-oxoethyl)-4-formyl-1,4,7-triazacyclononane; With hydrogenchloride; In methanol; water; at 20 ℃; for 48h;

With sodium hydroxide; In water; pH=> 13;
DOI:10.1016/j.poly.2012.10.029

Reference yield:

: 182274-80-2
N-(4-(1,3-benzothiazol-2-yl)phenyl)-2-chloroacetamide

: 1430238-18-8
1-(2-(4-(1,3-benzothiazol-2-yl)phenylamino)-2-oxoethyl)-1,4,7-triazacyclononane

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile / 48 h / Reflux; Inert atmosphere

2.1: water / 4 h / Reflux

3.1: hydrogenchloride / methanol; water / 48 h / 20 °C

3.2: pH > 13

With hydrogenchloride; water; In methanol; water; acetonitrile;
DOI:10.1016/j.poly.2012.10.029

Reference yield:

: 150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid

: 1430238-18-8
1-(2-(4-(1,3-benzothiazol-2-yl)phenylamino)-2-oxoethyl)-1,4,7-triazacyclononane

Guidance literature:: Multi-step reaction with 5 steps

1.1: polyphosphoric acid / 150 °C / Inert atmosphere

1.2: 9 h / 220 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 48 h / 20 °C / Inert atmosphere

3.1: acetonitrile / 48 h / Reflux; Inert atmosphere

4.1: water / 4 h / Reflux

5.1: hydrogenchloride / methanol; water / 48 h / 20 °C

5.2: pH > 13

With hydrogenchloride; water; triethylamine; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.poly.2012.10.029