2-(tert-butyl)-2,3-dihydro-3-phenyl-1,2-benzoisoxazole

Base Information

• Chemical Name: 2-(tert-butyl)-2,3-dihydro-3-phenyl-1,2-benzoisoxazole
• CAS No.: 1253786-03-6
• Molecular Formula: C₁₇H₁₉NO
• Molecular Weight: 253.344
• Mol file: 1253786-03-6.mol

Synonyms:2-(tert-butyl)-2,3-dihydro-3-phenyl-1,2-benzoisoxazole

Chemical Property of 2-(tert-butyl)-2,3-dihydro-3-phenyl-1,2-benzoisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(tert-butyl)-2,3-dihydro-3-phenyl-1,2-benzoisoxazole

There total 19 articles about 2-(tert-butyl)-2,3-dihydro-3-phenyl-1,2-benzoisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-tert-butyl-α-phenylnitrone (3376-24-7,68315-30-0) + 2-iodophenyltrifluoromethanesulfonic acid (129112-26-1) → 2-(tert-butyl)-2,3-dihydro-3-phenyl-1,2-benzoisoxazole (1253786-03-6)

Guidance literature:

With triethylsilane; cesium fluoride; In acetonitrile; at 70 ℃; for 24h; Reagent/catalyst; Inert atmosphere;

DOI:10.1021/acs.orglett.1c00279

Reference yield: 96.3%

N-tert-butyl-α-phenylnitrone (3376-24-7,68315-30-0) + 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl trifluoromethanesulfonate (1437769-72-6) → 2-(tert-butyl)-2,3-dihydro-3-phenyl-1,2-benzoisoxazole (1253786-03-6)

Guidance literature:

With sec.-butyllithium; In diethyl ether; hexane; cyclohexane; at -78 - 25 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ol401140d

Reference yield: 96.0%

N-tert-butyl-α-phenylnitrone (3376-24-7,68315-30-0) + 2-hydroxyphenyl boronic acid (89466-08-0) → 2-(tert-butyl)-2,3-dihydro-3-phenyl-1,2-benzoisoxazole (1253786-03-6)

Guidance literature:

2-hydroxyphenyl boronic acid; With 2,2-Dimethyl-1,3-propanediol; In dichloromethane; at 20 ℃; for 3h; Schlenk technique; Inert atmosphere;

With toluene; Inert atmosphere;

N-tert-butyl-α-phenylnitrone; With Nonafluorobutanesulfonyl fluoride; sodium hydride; caesium carbonate; In tetrahydrofuran; paraffin oil; at 60 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.9b03169

upstream raw materials:

2-tert-butyl-3-phenyloxaziridine

2-(trimethylsilyl)phenyl trifluoromethanesulfonate

2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

2-hydroxyphenyl boronic acid