Technology Process of Spiro[4.4]nonan-1-one, 6-amino-, (5S,6S)- (9CI)
There total 9 articles about Spiro[4.4]nonan-1-one, 6-amino-, (5S,6S)- (9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 40 percent / baker's yeast; CuO; 20 percent aq. sucrose / 24 h / 20 °C
2: Jones' reagent / acetone
3: t-BuLi; DIBAL-H / tetrahydrofuran / -78 °C
4: 99 percent / pyridine / 24 h / 0 - 20 °C
5: 76 percent / NaN3 / dimethylsulfoxide / 24 h / 80 °C
6: 14 percent / LDA / tetrahydrofuran / 8 h / 0 °C
7: H2 / 10 percentPd/C / ethanol / 24 h / 760 Torr
With
pyridine; sodium azide; baker's yeast; jones' reagent; hydrogen; tert.-butyl lithium; diisobutylaluminium hydride; copper(II) oxide; lithium diisopropyl amide; Sucrose;
10% palladium on active carbon;
In
tetrahydrofuran; ethanol; dimethyl sulfoxide; acetone;
1: stereoselective reduction / 2: Oxidation / 3: Reduction / 4: mesylation / 5: Substitution / 6: Cyclization / 7: Reduction;
DOI:10.1016/S0957-4166(00)00242-1
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 99 percent / pyridine / 24 h / 0 - 20 °C
2: 76 percent / NaN3 / dimethylsulfoxide / 24 h / 80 °C
3: 14 percent / LDA / tetrahydrofuran / 8 h / 0 °C
4: H2 / 10 percentPd/C / ethanol / 24 h / 760 Torr
With
pyridine; sodium azide; hydrogen; lithium diisopropyl amide;
10% palladium on active carbon;
In
tetrahydrofuran; ethanol; dimethyl sulfoxide;
1: mesylation / 2: Substitution / 3: Cyclization / 4: Reduction;
DOI:10.1016/S0957-4166(00)00242-1
