(E)-1-(2-(3-aminoprop-1-en-1-yl)benzyl)-6-fluoro-N-(1,2,4-thiadiazol-5-yl)-1H-indazole-5-sulfonamide trifluoroacetate

Base Information

Chemical Name:(E)-1-(2-(3-aminoprop-1-en-1-yl)benzyl)-6-fluoro-N-(1,2,4-thiadiazol-5-yl)-1H-indazole-5-sulfonamide trifluoroacetate
CAS No.:1608479-65-7
Molecular Formula:C₂HF₃O₂*C₁₉H₁₇FN₆O₂S₂
Molecular Weight:558.537
Hs Code.:

Synonyms:(E)-1-(2-(3-aminoprop-1-en-1-yl)benzyl)-6-fluoro-N-(1,2,4-thiadiazol-5-yl)-1H-indazole-5-sulfonamide trifluoroacetate

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Chemical Property of (E)-1-(2-(3-aminoprop-1-en-1-yl)benzyl)-6-fluoro-N-(1,2,4-thiadiazol-5-yl)-1H-indazole-5-sulfonamide trifluoroacetate

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Technology Process of (E)-1-(2-(3-aminoprop-1-en-1-yl)benzyl)-6-fluoro-N-(1,2,4-thiadiazol-5-yl)-1H-indazole-5-sulfonamide trifluoroacetate

There total 6 articles about (E)-1-(2-(3-aminoprop-1-en-1-yl)benzyl)-6-fluoro-N-(1,2,4-thiadiazol-5-yl)-1H-indazole-5-sulfonamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₃₅FN₆O₆S₂

: 76-05-1
trifluoroacetic acid

: 1608479-65-7
(E)-1-(2-(3-aminoprop-1-en-1-yl)benzyl)-6-fluoro-N-(1,2,4-thiadiazol-5-yl)-1H-indazole-5-sulfonamide trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1608480-98-3
5-(benzylthio)-6-fluoro-1-(2-iodobenzyl)-1H-indazole

: 1608479-65-7
(E)-1-(2-(3-aminoprop-1-en-1-yl)benzyl)-6-fluoro-N-(1,2,4-thiadiazol-5-yl)-1H-indazole-5-sulfonamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,3-dichloro-5,5-dimethylhydantoin / acetonitrile; water; acetic acid / -78 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: -78 - 20 °C

3.1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 0.17 h / 120 °C / Microwave irradiation

4.1: dichloromethane / 1 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,3-dichloro-5,5-dimethylhydantoin; caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; acetic acid; acetonitrile;

Reference yield:

: 1608480-95-0
5-(benzylthio)-6-fluoro-1H-indazole

: 1608479-65-7
(E)-1-(2-(3-aminoprop-1-en-1-yl)benzyl)-6-fluoro-N-(1,2,4-thiadiazol-5-yl)-1H-indazole-5-sulfonamide trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 20 °C

2.1: 1,3-dichloro-5,5-dimethylhydantoin / acetonitrile; water; acetic acid / -78 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: -78 - 20 °C

4.1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 0.17 h / 120 °C / Microwave irradiation

5.1: dichloromethane / 1 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,3-dichloro-5,5-dimethylhydantoin; caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetic acid; acetonitrile;